FOLR4 Antibody (12A5) [PE]

Product Discontinued

FOLR4 Antibody (12A5) [PE] Summary

• Immunogen: CD3 mAb-stimulated CD4/CD25 T cells
• Isotype: IgG2b Kappa
• Clonality: Monoclonal
• Host: Rat
• Gene: IZUMO1R
• Purity: Protein G purified

Applications/Dilutions

• Dilutions:
  • Flow Cytometry 1ul/1 million cells

Reactivity Notes

Mouse

Packaging, Storage & Formulations

• Storage: Store at 4C in the dark.
• Buffer: PBS
• Preservative: 0.05% Sodium Azide
• Purity: Protein G purified

Alternate Names for FOLR4 Antibody (12A5) [PE]

• folate receptor 4 (delta) homolog (mouse)
• Folbp3
• FOLR4
• FR-delta
• LOC390243
• probable folate receptor delta

Background

Folates represent an important role in protein and nucleic acid biosynthesis and are recognized in particular for their role in spinal canal and brain development during early pregnancy. Folate receptor 4 (FR4) is expressed at high levels in both natural and TGF-b-induced Treg cells. A majority of the CD4+ Tregs express FR4 along with CD25 and FoxP3. In addition, there are functional similarities in regulating immune response by FoxP3 and FR4 expressing CD4+ Tregs which express CD25 as well. CD4+CD25+FR4hi T cell population may be used as a functional immuno-suppressor Treg population which should express FoxP3. The folate receptor antibodies produced by clones 12A5 and TH6 recognize a subtype of the receptor for the vitamin (folic acid) known as folate receptor d, and folate-binding protein 3. Accordingly, FR4 antibodies may be used for the easy isolation (both FACS and magnetic beads sorting) and staining of Tregs using simple surface staining while keeping the Tregs viable for subsequent down stream applications.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: IZUMO1R