FBXL6 Antibody

Product Discontinued

FBXL6 Antibody Summary

• Description: Please note, this antibody is considered Innovators Grade. Innovators Grade antibodies are generally unvalidated and require additional characterization for most new species/applications. Novus has made these antibodies available through our Innovators Reward program. Complete an online review with image, detailing your positive or negative results. In return, you receive a discount voucher for 100% of the purchase price of the reviewed product. Please contact us at innovators@novusbio.com for more details.
• Immunogen: Peptide with sequence CLEQLLTSPSPS corresponding to C-Terminus according to NP_036294.1, NP_078831.3.
• Specificity: This is expected to recognise reported human isoforms (NP_036294.1 and NP_078831.3).
• Isotype: IgG
• Clonality: Polyclonal
• Host: Goat
• Gene: FBXL6
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Peptide ELISA Detection limit 1:8000
• Application Notes: WB: No signal obtained yet but low background observed in human kidney and heart extracts at up to 1 ug/ml.

Packaging, Storage & Formulations

• Storage: Store at -20C. Avoid freeze-thaw cycles.
• Buffer: Tris saline (20 mM Tris pH 7.3, 150 mM NaCl), 0.5% BSA
• Preservative: 0.02% Sodium Azide
• Concentration: 0.5 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for FBXL6 Antibody

• FBL6A
• F-box and leucine-rich repeat protein 6FBL6F-box protein FBL6
• F-box/LRR-repeat protein 6
• PP14630

Background

This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternative splicing of this gene generates 2 transcript variants.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for FBXL6 Antibody (NB100-1291)(1)

Publication using NB100-1291

• Winston JT, Koepp DM, Zhu C et al. A family of mammalian F-box proteins. Curr Biol 1999-10-21 [PMID: 10531037]

Bioinformatics

• Gene Symbol: FBXL6
• Entrez:
  • 26233(Human)
  • 30840(Mouse)
• Uniprot:
  • NP_036294(Human)