CLEC2L Antibody (2326G) [Alexa Fluor™ Plus 647]

• Reactivity: Hu
• Clone: 2326G
• Clonality: Monoclonal
• Host: Rabbit
• Conjugate: Alexa Fluor Plus 647

CLEC2L Antibody (2326G) [Alexa Fluor™ Plus 647] Summary

• Specificity: Detects human CLEC2L in direct ELISA.
• Isotype: IgG
• Clonality: Monoclonal
• Host: Rabbit

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for CLEC2L Antibody (2326G) [Alexa Fluor™ Plus 647]

• CLEC2L
• C-type lectin domain family 2 member L
• C-type lectin domain family 2, member L

Background

C-type lectin domain family 2, member L (CLEC2L), is a type II transmembrane protein of the CLEC2 family of proteins that includes CD69, LLT1, AICL and KACL (1, 2). CLEC2 family members have broad tissue expression, with LLT1, AICL and KACL expressed on B cells, monocytes, and keratinocytes, respectively (3-5). In contrast, CLEC2L, a homodimeric cell surface receptor, is predominantly expressed in the brain and is referred to as the brain-associated C-type lectin (BACL) (6). Mature human CLEC2L includes a 68 amino acid (aa) cytoplasmic domain, a 21 aa transmembrane segment, and a 125 aa extracellular domain (ECD). Within the ECD, human CLEC2L shares 94% aa sequence identity with mouse and rat CLEC2L. Our assay shows that CLEC2L binds to Galectin-3.

1. Yokoyama, W.M. and B.F. Plougastel (2003) Nat. Rev. Immunol. 3:304.
2. Vogler, I. and A. Steinle (2011) J. Innate Immune. 3:227.
3. Welte, S. et al. (2006) Nat. Immunol. 7:1334.
4. Spreu, J. et al. (2010) Proc. Natl. Acad. Sci. USA 107:5100.
5. Rosen, D.B. et al. (2008) J. Immunol. 180:6508.
6. Lysenko, O. et al. (2013) PloS One. 8:e65345.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.