| Reactivity | MuSpecies Glossary |
| Applications | ICC/IF |
| Clone | 919916 |
| Clonality | Monoclonal |
| Host | Rat |
| Conjugate | Alexa Fluor 647 |
| Immunogen | E. coli-derived recombinant mouse Caspase-11/Caspase-4 Pro81-Glu266 Accession # P70343 |
| Specificity | Detects mouse Caspase-11/Caspase-4 in direct ELISA. |
| Isotype | IgG2b |
| Clonality | Monoclonal |
| Host | Rat |
| Purity Statement | Protein A or G purified |
| Innovator's Reward | Test in a species/application not listed above to receive a full credit towards a future purchase. |
| Storage | Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied |
| Buffer | Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide |
Mouse Caspase-11 (commonly referred as Caspase-4) is a member of the cysteine-aspartic acid protease family known as caspases that function in initiating apoptosis or activating proinflammitory cytokines. Mouse Caspase-11 is expressed as a 343 amino acid latent zymogen. The active caspase-11 is cleaved into two subunits, p20 (aa 81-266) and p10 (aa 286-373). Caspase-11 is one of several caspases associated with the inflammasome and plays an important role in the activation of proinflammatory cytokines. Caspase-11 is activated by an autocatalytic mechanism or by cleavage by Caspase-8 in response to ER stress or bacterial infection, and its expression and activation can be induced by exposure to LPS. The active enzyme can cleave and activate Caspase-1 which in turn activates IL-1 beta. Mouse Caspase-11 has a 59 and 89% homology to human and rat Caspase-4, respectively.
Secondary Antibodies |
Isotype Controls |
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