BTNL8 Antibody (2187B) [Alexa Fluor® 594]


There are currently no images for BTNL8 Antibody (FAB9359T).

Every product we sell is backed by Novus' 100% Guarantee. If you have used this product, please submit your images and reviews to earn reward points.

Product Details

Reactivity HuSpecies Glossary
Applications Flow
Alexa Fluor 594

BTNL8 Antibody (2187B) [Alexa Fluor® 594] Summary

Additional Information
Recombinant Monoclonal Antibody
Human embryonic kidney cell line HEK-293-derived Human BTNL8
Accession # Q6UX41-1
Detects human BTNL8 in direct ELISAs and Western blots.
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.


  • Flow Cytometry 0.25-1 ug/10^6 cells

Packaging, Storage & Formulations

Protect from light. Do not freeze.
  • 12 months from date of receipt, 2 to 8 °C as supplied.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.


This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for BTNL8 Antibody (2187B) [Alexa Fluor® 594]

  • BTN9.2
  • BTNL8
  • butyrophilin-like 8
  • butyrophilin-like protein 8
  • UNQ702/PRO1347


Butyrophilin-like 8 (BTNL8) is a member of the BTN/MOG Ig-superfamily and functions as a negative regulator of immune cell activation (1). Human BTNL8 is a 500 amino acid (aa) type I transmembrane glycoprotein that contains a signal peptide followed by an extracellular domain (ECD), a transmembrane region and a short cytoplasmic domain (2). The ECD of human BTNL8 shares 88% sequence identity with the ECD of mouse BTNL8. BTNL8 has two alternatively spliced forms: B7-like and BTN-like. Both isoforms of BTNL8 are expressed in a range of human tissues (3). The complete immunological function of BTNL molecules is only beginning to emerge. BTNL8 has been shown to be important in initiation of primary immune responses, suggesting a role in priming of naïve T lymphocytes (3). Down-regulation of BNTL8 mRNA levels has been associated with ulcerative colitis and colon cancer (4). BTNL8 are expressed in colon, lung, testis and neutrophils, and its expression is significantly decreased in ulcerative colitis, colonic tumors as compared to unaffected tissue (4). Soluble BTNL8-Fc fusion protein binds to resting, but not activated T cells. In vitro, BTNL8 co-stimulates T cell proliferation and cytokine production. In vivo injections of BTNL8-Fc significantly increases production of
Ag-specific IgG during the primary but not the secondary immune response (3).
  1. Arnett, H.A. et al. (2007) J. Immunol. 178:1523.
  2. Arnett, H.A. et al. (2009) Cytokine 46:370.
  3. Chapoval, A.I. et al. (2013) Mol Immunol. 56:819.
  4. Lebrero-Fernández C. et al. (2016) Immun Inflamm Dis. 4:191.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for BTNL8 Antibody (FAB9359T) (0)

There are no publications for BTNL8 Antibody (FAB9359T).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for BTNL8 Antibody (FAB9359T) (0)

There are no reviews for BTNL8 Antibody (FAB9359T). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

FAQs for BTNL8 Antibody (FAB9359T) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Customers Who Bought This Also Bought

Contact Information

Product PDFs


Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.


Review this Product

Be the first to review our BTNL8 Antibody (2187B) [Alexa Fluor® 594] and receive a gift card or discount.