BTNL8 Antibody (2187B) [Alexa Fluor® 594] Summary
Recombinant Monoclonal Antibody
Human embryonic kidney cell line HEK-293-derived Human BTNL8
Accession # Q6UX41-1
Detects human BTNL8 in direct ELISAs and Western blots.
Test in a species/application not listed above to receive a full credit towards a future purchase.
- Flow Cytometry 0.25-1 ug/10^6 cells
Packaging, Storage & Formulations
|Protect from light. Do not freeze.
- 12 months from date of receipt, 2 to 8 °C as supplied.
Supplied 0.2 mg/mL in a saline solution containing BSA and Sodium Azide.
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for BTNL8 Antibody (2187B) [Alexa Fluor® 594]
- butyrophilin-like 8
- butyrophilin-like protein 8
8 (BTNL8) is a member of the BTN/MOG Ig-superfamily and functions as a negative
regulator of immune cell activation (1). Human BTNL8 is a 500 amino acid (aa) type I
transmembrane glycoprotein that contains a signal peptide followed by an
extracellular domain (ECD), a transmembrane region and a short cytoplasmic
domain (2). The ECD of human BTNL8 shares 88% sequence identity with the
ECD of mouse BTNL8. BTNL8 has two alternatively spliced forms: B7-like and
BTN-like. Both isoforms of BTNL8 are expressed in a range of human tissues (3).
The complete immunological function of BTNL molecules is only beginning to
emerge. BTNL8 has been shown to be important in initiation of primary immune
responses, suggesting a role in priming of naïve T lymphocytes (3). Down-regulation of BNTL8 mRNA levels has been associated with ulcerative colitis and
colon cancer (4). BTNL8
are expressed in colon, lung, testis and neutrophils, and its expression is
significantly decreased in ulcerative colitis, colonic tumors as compared to
unaffected tissue (4). Soluble BTNL8-Fc fusion protein binds to resting, but
not activated T cells. In vitro
BTNL8 co-stimulates T cell proliferation and cytokine production. In
vivo injections of BTNL8-Fc significantly increases
Ag-specific IgG during the primary but not the secondary immune
Arnett, H.A. et al. (2007) J. Immunol. 178:1523.
- Arnett, H.A. et al. (2009) Cytokine 46:370.
- Chapoval, A.I. et al. (2013) Mol Immunol. 56:819.
- Lebrero-Fernández C. et al. (2016) Immun Inflamm Dis. 4:191.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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