alpha 1B-Glycoprotein Antibody [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB
• Clonality: Polyclonal
• Host: Sheep
• Conjugate: Alexa Fluor 647

alpha 1B-Glycoprotein Antibody [Alexa Fluor® 647] Summary

• Immunogen: Human embryonic kidney cell line HEK293-derived recombinant human α 1B-Glycoprotein
  Ala22-Ser495
  Accession # EAW72575
• Specificity: Detects human alpha 1B-Glycoprotein in direct ELISAs and Western blots.
• Isotype: IgG
• Clonality: Polyclonal
• Host: Sheep
• Purity Statement: Antigen Affinity-purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for alpha 1B-Glycoprotein Antibody [Alexa Fluor® 647]

• A1B
• A1BG
• ABG
• alpha 1BGlycoprotein
• alpha 1B-Glycoprotein
• Alpha-1-B glycoprotein;alpha1B-glycoprotein;Alpha-1B-glycoprotein;alpha-1-B-glycoprotein;DKFZp686F0970;epididymis secretory sperm binding protein Li 163pA;HEL-S-163pA
• GAB

Background

A1BG (alpha-1 B/beta-glycoprotein; also C44 [in rodent]) is a 68-80 kDa monomeric plasma glycoprotein member of the Immunoglobulin superfamily of molecules. It is expressed by multiple cell types, principally hepatocytes in response to circulating growth hormone. Initially thought to act as an MMP inhibitor, A1BG is now known to bind to CRISP3, a distant member of a family of venomous molecules. CRISP3 is widely expressed and possesses no toxic properties. But it may play a key role in fertilization, where it temporarily blocks the reaction of PMNs to sperm in the uterus, thus increasing sperm lifespan and the likelihood of fertilization. Within this context, A1BG may regulate CRISP3 availability. A1BG has also been investigated as a biomarker in various cancers. Mature human A1BG is 474 amino acids (aa) in length (aa 22-495) and contains five V-type Ig-like domains. There is one isoform variant that utilizes Met123 as an alternative start site. Full-length human A1BG (aa 22-495) shares only 44% aa sequence identity with mouse A1BG.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.