4-amino Biphenyl DNA Antibody (4C11)

Images

 
Immunohistochemistry: 4-amino Biphenyl DNA Antibody (4C11) [NB100-415] - Human breast tumor tissue with high (A) and low (B) adduct levels. Images courtesy of Dr. Regina Santella.

Product Details

Summary
Reactivity Mu, AllSpecies Glossary
Applications ELISA, ICC/IF, IHC
Clone
4C11
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

4-amino Biphenyl DNA Antibody (4C11) Summary

Immunogen
4-amino Biphenyl DNA
Localization
Nuclear
Clonality
Monoclonal
Host
Mouse
Purity
Unpurified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:50 1:100
  • Immunohistochemistry 1:50-1:100
Application Notes
This 4-amino Biphenyl DNA (4C11) antibody is useful for ELISA, Immunocytochemistry/Immunofluorescence and Immunohistochemistry.
Publications
Read Publications using
NB100-415 in the following applications:

  • IHC
    1 publication

Reactivity Notes

Detects DNA from all species Mouse reactivity reported in scientific literature (PMID: 12700401).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Ascites
Preservative
0.1% Sodium Azide
Purity
Unpurified

Alternate Names for 4-amino Biphenyl DNA Antibody (4C11)

  • 4-AMBP DNA
  • 4-aminobiphenyl DNA
  • 4-amino-Biphenyl DNA

Background

4-amino Biphenyl (4-ABP) is an arylamine (aromatic amine) compound and as one of the major carcinogenic constituents of tobacco smoke other environmental sources, it poses critical health hazards to human beings. Under the action of carcinogen activating biotransformation enzymes such as cytochrome P4501A2, 4-ABP gets metabolized to generate a direct-acting mutagen known as N-hydroxy-aminobiphenyl. Nevertheless, the accumulation of biologically active metabolites is dependent on the balance between activation and detoxification enzymes. 4-ABP has been linked to bladder and breast cancers in human beings as well as in rodent models. Our 4-amino Biphenyl DNA antibody (4C11) is a monoclonal antiserum which recognizes 4-aminobiphenyl (4-ABP)-DNA adducts and it has been characterized by competitive enzyme-linked immunosorbent assay (ELISA), immunohistochemistry (IHC) and Immunocytochemistry/Immunofluorescence (ICC/IF) techniques. This antibody does not recognize the DNA adducts of several other aromatic amines tested including 1-aminopyrene, 8-nitro-1-aminopyrene, and 6-nitro-1-aminopyrene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Publications for 4-amino Biphenyl DNA Antibody (NB100-415)(4)

We have publications tested in 1 confirmed species: Mouse.

We have publications tested in 1 application: IHC.


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IHC
(1)
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Mouse
(1)
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Product General Protocols

View specific protocols for 4-amino Biphenyl DNA Antibody (NB100-415): Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

ICC/IF Video Protocol

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Secondary Antibodies

 

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