PKR Products

Description

The protein encoded by this gene is a serine/threonine protein kinase that is activated by autophosphorylation after binding to dsRNA. The activated form of the encoded protein can phosphorylate translation initiation factor EIF2S1, which in turn inhibits protein synthesis. This protein is also activated by manganese ions and heparin. The encoded protein plays an important role in the innate immune response against multiple DNA and RNA viruses.

Bioinformatics

Entrez	5610 Human
Uniprot	AAP57628 Human NM_002759 Human NP_001129123 Human NP_002750 Human NP_002750.1 Human P19525 Human
Product By Gene ID	5610
Alternate Names	double stranded RNA activated protein kinase EC 2.7.11.1 eIF-2A protein kinase 2 EIF2AK1 eukaryotic translation initiation factor 2-alpha kinase 2P1/eIF-2A protein kinase interferon-induced, double-stranded RNA-activated protein kinase interferon-inducible double stranded RNA dependent interferon-inducible elF2alpha kinase Interferon-inducible RNA-dependent protein kinase PKRp68 kinase PRKRMGC126524 Protein kinase RNA-activated

Research Areas for PKR

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Phospho-Specific
Signal Transduction

Related PKR Blog Posts

Check out the latest blog posts on PKR.

PKR - Mediating cellular stress responses through multiple signaling pathways Protein kinase R (PKR) is an intracellular stress-sensing protein that is able to detect and respond to viral infections. While PKR is able to sense and respond to a variety of signals, dsRNA is a well-characterized ligand. dsRNA produced during v...    Read more.

eIF2alpha - a regulator of global translation in response to cellular stress Eukaryotic initiation factor 2 (eIF2) regulates global protein translation by binding to Met-tRNA and the 40S ribosome to form the pre-initiation complex. eIF2 is a heterotrimer consisting of alpha, beta, and gamma subunits. The 36kDA eIF2a subuni...    Read more.

Read more PKR related blogs.