RKIP/PBP Products

Description

PBP, also known as RKIP (RAF kinase inhibitor protein), binds ATP, opioids and phosphatidylethanolamine. PBP is able to regulate Aurora kinase B expression and the spindle checkpoint through interaction with the RAF1/MEK/ERK cascade. PBP is able to bind to RAF1 and MEK and competitively disrupt the interaction between these proteins. PBP may be involved in the function of the presynaptic cholinergic neurons of the central nervous system. It increases the production of choline acetyltransferase but not acetylcholinesterase. PBP has been implicated as a suppressor of metastasis.

Bioinformatics

Entrez	5037 Human
Uniprot	AAH31102 Human
Product By Gene ID	5037
Alternate Names	HCNP HCNPpp hippocampal cholinergic neurostimulating peptide Neuropolypeptide h3 PBP PBPPEBP-1 PEBP1 PEBP-1 PEBPHCNPpp phosphatidylethanolamine binding protein 1 phosphatidylethanolamine-binding protein 1 prostatic binding protein Prostatic-binding protein Raf kinase inhibitory protein RKIP RKIPRaf kinase inhibitor protein

Research Areas for RKIP/PBP

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Cancer