NEDD8 Products

Description

NEDD8 belongs to the ubiquitin family and human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The NEDD8 system is essential for the regulation of protein degradation pathways involved in cell cycle progression, morphogenesis and tumorigenesis. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. Recombinant human NEDD8 protein was expressed in E.coli and purified by using conventional chromatography techniques, after refolding of the isolated inclusion body in renaturation buffer.

Bioinformatics

Product By Gene ID	4738
Alternate Names	FLJ43224 MGC104393 MGC125896 MGC125897 NEDD8 NEDD-8 Neddylin Neural precursor cell expressed developmentally down-regulated protein 8 neural precursor cell expressed, developmentally down-regulated 8 Rub1 Ubiquitin-like protein Nedd8

Research Areas for NEDD8

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Cancer

Related NEDD8 Blog Posts

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PINK1: All work and no fun The protein PINK1 is a mitochondrial-located serine/threonine kinase (PTK) that maintains organelle function and integrity. It not only protects organelles from cellular stress, but it also uses the selective auto-phagocytosis process for cleaning and...    Read more.

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