MUL1 Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID

79594

Alternate Names

C1orf166mitochondrial E3 ubiquitin ligase 1 E3 ubiquitin-protein ligase MUL1 EC 6.3.2 EC 6.3.2.- FLJ12875 GIDERP11-401M16.2 Growth inhibition and death E3 ligase MAPLE3 ubiquitin ligase mitochondrial E3 ubiquitin protein ligase 1 mitochondrial ubiquitin ligase activator of NFKB 1 mitochondrial ubiquitin ligase activator of NF-kB Mitochondrial-anchored protein ligase MULANchromosome 1 open reading frame 166 Putative NF-kappa-B-activating protein 266 RING finger protein 218 RNF218mitochondria-anchored protein ligase

Research Areas for MUL1

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Signal Transduction

Related MUL1 Blog Posts

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MUL1 - A Mito's best friend MUL1 is an E3 ubiquitin-protein ligase with a RING finger domain that controls mitochondrial morphology, fragmentation and localization. E3 ubiquitin ligases accept the component ubiquitin from a donor E2 ubiquitin-conjugating directly transfer this u...    Read more.

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