MTHFD2 Products

Description

MTHFD2 encodes a nuclear-encoded mitochondrial bifunctional enzyme with methylenetetrahydrofolate dehydrogenase and methenyltetrahydrofolate cyclohydrolase activities. The enzyme functions as a homodimer and is unique in its absolute requirement for magnesium and inorganic phosphate. Formation of the enzyme-magnesium complex allows binding of NAD. Alternative splicing results in multiple transcripts encoding different isoforms. This gene has a pseudogene on chromosome 7.

Bioinformatics

Entrez	10797 Human
Uniprot	AAH01548 Human NM_001040409 Human NM_006636 Human P13995 Human
Product By Gene ID	10797
Alternate Names	bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase methenyltetrahydrofolate cyclohydrolase methenyltetrahydrofolate cyclohydrolase methylene tetrahydrofolate dehydrogenase (NAD+ dependent) methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 mitochondrial NAD-dependent methylene tetrahydrofolate dehydrogenase cyclohydrolase NMDMC

Research Areas for MTHFD2

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Core ESC-Like Genes
Stem Cell Markers

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