MMP-14/MT1-MMP Products

Description

The matrix metalloproteinase (MMP) family (approximately 25 members in mammals) has been implicated in extracellular matrix remodeling associated with embryonic development, cancer formation and progression, and various other physiological and pathological events. MMP-14 is a membrane-bound matrix metalloproteinase (MT-MMP) capable of mediating pericellular proteolysis of extracellular matrix components. MMP-14 is therefore thought to be an important molecular tool for cellular remodeling of the surrounding matrix (1). Gelatinase A (type-IV collagenase; M(r) 72,000) is produced by tumour stroma cells and is believed to be crucial for their invasion and metastasis, acting by degrading extracellular matrix macro-molecules such as type IV collagen. MMP-14 may thus trigger invasion by tumor cells by activating pro-gelatinase A on the tumor cell surface (2). Observations identify MT1-MMP as a tumor-derived growth factor that regulates proliferation by controlling cell geometry within the confines of the 3D extracellular matrix (ECM) (3).

Bioinformatics

Entrez	17387 Mouse 4323 Human 81707 Rat
Uniprot	AAH64803 Human AAH64803.1 Human MM14_HUMAN Human NM_004995 Human P50281 Human
Product By Gene ID	4323
Alternate Names	EC 3.4.24 EC 3.4.24.80 matrix metallopeptidase 14 (membrane-inserted) matrix metalloproteinase 14 (membrane-inserted) matrix metalloproteinase-14 membrane type 1 metalloprotease Membrane-type matrix metalloproteinase 1 Membrane-type-1 matrix metalloproteinase MMP-14 MMP-X1 MT1MMP MT1-MMPMTMMP1 MT-MMP 1

Research Areas for MMP-14/MT1-MMP

Find related products by research area and learn more about each of the different research areas below.

Cancer
Extracellular Matrix