IRAK3 Products

Description

IRAK3 is a novel member in the IRAK/Pelle family. IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and play a central role in IL-1R/TLR mediated inflammatory responses. Interleukin-1 (IL-1) and lipopolysaccharide (LPS)induces cellular response through IL-1 receptor (IL-1R) and Toll like receptors (TLR). IL-1 receptor associated kinase (IRAK and IRAK2) mediates the activation of NF-kB by IL-1/Toll receptors (Wesche H et al.1999,Muzio M et al.1997), which is a pivotal transcription factor mediating inflammatory and immune response. A novel member in theIRAK/Pelle family was recently identified and designated IRAK-M (Cao Z et al.1996). IRAKs associate with IL-1/Toll receptors after IL-1 or LPS stimulation and thedominant negative mutants of IRAKs inhibit IL-1 orLPS induced NF-kB activation. Members inIRAK/Pelle family play a central role in IL-1R/TLRmediated inflammatory responses to cytokine IL-1and LPS.

Bioinformatics

Entrez	11213 Human 314870 Rat 73914 Mouse
Uniprot	AAD40879 Human AAH57800 Human AF113136 Human NM_007199 Human NP_009130 Human NP_082955.2 Mouse Q9Y616 Human
Product By Gene ID	11213
Alternate Names	ASRT5 EC 2.7.11.1 FLJ13601 IL-1 receptor-associated kinase M interleukin-1 receptor-associated kinase 3 IRAK-3 IRAKM IRAK-M

Research Areas for IRAK3

Find related products by research area and learn more about each of the different research areas below.

Cytokine Research
Immunology
Innate Immunity
Protein Kinase