TEM5/GPR124 Products

Description

Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID	25960
Alternate Names	DKFZp434C211 DKFZp434J0911 G protein-coupled receptor 124 GPR124 G-protein coupled receptor 124 KIAA1531 KIAA1531FLJ14390 TEM5 TEM5Tumor endothelial marker 5

Research Areas for TEM5/GPR124

Find related products by research area and learn more about each of the different research areas below.

Cancer
Endothelial Cell Markers
GPCR