Factor VIII Products

Description

Hemostasis following tissue injury involves the deployment of essential plasma procoagulants (prothrombin, and Factors X, IX, V, and VIII), which are involved in a blood coagulation cascade that leads to the formation of insoluble fibrin clots and the promotion of platelet aggregation. Coagulation factor VIII is a 2351 amino acid, non-covalent heterodimer, that circulates as an inactive procofactor. When catalyzed by thrombin, factor VIII is converted to active Factor VIIIa, which associates with factor IXa. This complex catalyzes the conversion of factor X to factor Xa. This results in the amplification phase of coagulation. [PMID: 16513527]

Bioinformatics

Entrez	2157 Human 14069 Mouse
Uniprot	P00451 Human
Product By Gene ID	2157
Alternate Names	AHF Antihemophilic factor coagulation factor VIII, procoagulant component coagulation factor VIIIc DXS1253E F8Ccoagulation factor VIII factor VIII F8B FVIII HEMAF8B Procoagulant component

Research Areas for Factor VIII

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Cardiovascular Biology

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Factor VIII - a key factor in the clotting process Hemostasis, or blood clotting, follows tissue injury and involves the deployment of essential plasma procoagulants (such as prothrombin, and Factors X, IX, V, and VIII) that trigger the blood coagulation cascade. This cascade leads to the formation...    Read more.

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