ZP2 Products

Description

The zona pellucida is an extracellular matrix that surrounds the oocyte and early embryo. It is composed primarily of three or four glycoproteins with various functions during fertilization and preimplantation development. The protein encoded by this gene is a structural component of the zona pellucida and functions in secondary binding and penetration of acrosome-reacted spermatozoa. The nascent protein contains a N-terminal signal peptide sequence, a conserved ZP domain, a consensus furin cleavage site, and a C-terminal transmembrane domain. It is hypothesized that furin cleavage results in release of the mature protein from the plasma membrane for subsequent incorporation into the zona pellucida matrix. However, the requirement for furin cleavage in this process remains controversial based on mouse studies. [provided by RefSeq]

Bioinformatics

Entrez	7783 Human
Uniprot	AAH96305 Human AAH96305.1 Human NM_003460 Human NP_003451 Human NP_003451.1 Human Q05996 Human
Product By Gene ID	7783
Alternate Names	zona pellucida glycoprotein 2 (sperm receptor) Zona pellucida glycoprotein 2 zona pellucida glycoprotein ZP2 Zona pellucida protein A zona pellucida sperm-binding protein 2 Zp-2