Species: Hu
Applications: WB, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: ICC/IF
Host: Rabbit Polyclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB
Species: Hu
Applications: WB, ELISA, MA, AP
Species: Hu
Applications: AC
Species: Hu
Applications: AC
Description
ZFYVE9 encodes a double zinc finger (FYVE domain) protein that interacts directly with SMAD2 and SMAD3, and is involved in Alzheimer's disease. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs. The C-terminal domain of this protein interacts with the TGFB receptor. This protein is a component of the TGFB pathway that brings the SMAD substrate to the receptor. Three alternatively spliced transcripts encoding distinct isoforms have been found for this gene. [provided by RefSeq]
Bioinformatics
Entrez |
Human |
Uniprot |
Human Human Human |
Product By Gene ID |
9372 |
Alternate Names |
- Madh-interacting protein
- MADHIP
- mothers against decapentaplegic homolog interacting protein
- mothers against decapentaplegic homolog interacting protein, receptoractivation anchor
- NSP
- receptor activation anchor
- Receptor activation anchor
- SARAhSARA
- Smad anchor for receptor activation
- SMADIPMAD, mothers against decapentaplegic homolog (Drosophila) interacting protein
- zinc finger FYVE domain-containing protein 9
- zinc finger, FYVE domain containing 9
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Research Areas for ZFYVE9
Find related products by research area and learn more about each of the different research areas below.
Signal Transduction