ZFYVE9 Products

Description

ZFYVE9 encodes a double zinc finger (FYVE domain) protein that interacts directly with SMAD2 and SMAD3, and is involved in Alzheimer's disease. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs. The C-terminal domain of this protein interacts with the TGFB receptor. This protein is a component of the TGFB pathway that brings the SMAD substrate to the receptor. Three alternatively spliced transcripts encoding distinct isoforms have been found for this gene. [provided by RefSeq]

Bioinformatics

Entrez	9372 Human
Uniprot	NM_004799 Human NP_015562.1 Human NP_015563 Human
Product By Gene ID	9372
Alternate Names	Madh-interacting protein MADHIP mothers against decapentaplegic homolog interacting protein mothers against decapentaplegic homolog interacting protein, receptoractivation anchor NSP receptor activation anchor Receptor activation anchor SARAhSARA Smad anchor for receptor activation SMADIPMAD, mothers against decapentaplegic homolog (Drosophila) interacting protein zinc finger FYVE domain-containing protein 9 zinc finger, FYVE domain containing 9

Research Areas for ZFYVE9

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Signal Transduction