ZFYVE9 Products

Description

ZFYVE9 encodes a double zinc finger (FYVE domain) protein that interacts directly with SMAD2 and SMAD3, and is involved in Alzheimer's disease. SMAD proteins transmit signals from transmembrane serine/threonine kinase receptors to the nucleus. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs. The C-terminal domain of this protein interacts with the TGFB receptor. This protein is a component of the TGFB pathway that brings the SMAD substrate to the receptor. Three alternatively spliced transcripts encoding distinct isoforms have been found for this gene. [provided by RefSeq]

Bioinformatics

Entrez	9372 Human
Uniprot	NM_004799 Human NP_015562.1 Human NP_015563 Human
Product By Gene ID	9372
Alternate Names	MADHIP zinc finger FYVE domain-containing protein 9 Smad anchor for receptor activation mothers against decapentaplegic homolog interacting protein Receptor activation anchor mothers against decapentaplegic homolog interacting protein, receptoractivation anchor Madh-interacting protein receptor activation anchor SMADIPMAD, mothers against decapentaplegic homolog (Drosophila) interacting protein SARAhSARA NSP zinc finger, FYVE domain containing 9

Diseases related to ZFYVE9

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Lymphoma
B-cell Lymphomas

Research Areas for ZFYVE9

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Signal Transduction

PTMs for ZFYVE9

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Phosphorylation

Bioinformatics Tool for ZFYVE9

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