XPV/DNA polymerase eta Products

Description

This gene encodes a member of the Y family of specialized DNA polymerases. It copies undamaged DNA with a lower fidelity than other DNA-directed polymerases. However, it accurately replicates UV-damaged DNA; when thymine dimers are present, this polymerase inserts the complementary nucleotides in the newly synthesized DNA, thereby bypassing the lesion and suppressing the mutagenic effect of UV-induced DNA damage. This polymerase is thought to be involved in hypermutation during immunoglobulin class switch recombination. Mutations in this gene result in XPV, a variant type of xeroderma pigmentosum.

Bioinformatics

Entrez	5429 Human
Uniprot	NP_006493.1 Human
Product By Gene ID	5429
Alternate Names	DNA polymerase eta DNA Polymerase, eta EC 2.7.7.7 POLH polymerase (DNA directed), eta RAD30 homolog A RAD30 RAD30A RAD30AFLJ16395 Xeroderma pigmentosum variant type protein XPV XP-V XPVFLJ21978

Research Areas for XPV/DNA polymerase eta

Find related products by research area and learn more about each of the different research areas below.

DNA Polymerases
DNA Repair