WRN Products

Antibodies
WRN Antibody
WRN Antibody
NB100-472
Species: Hu, Mk, Pm
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
WRN Antibody
WRN Antibody
NBP1-31895
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Proteins
Recombinant Human WRN Protein ...
Recombinant Human WRN Protein
H00007486-Q01
Species: Hu
Applications: WB, ELISA, PA
WRN Recombinant Protein Antig ...
WRN Recombinant Protein Antigen
NBP1-87143PEP
Species: Hu
Applications: AC
RNAi
WRN RNAi
WRN RNAi
H00007486-R02
Species: Hu
Applications: RNAi, RNAi SP

Description

WRN encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner Syndrome, an autosomal recessive disorder characterized by premature aging.

Bioinformatics

Entrez Human
Uniprot Human
Human
Product By Gene ID 7486
Alternate Names
  • EC 3.6.1
  • Werner syndrome
  • RecQ3
  • DNA helicase, RecQ-like type 3
  • EC 3.6.4.12
  • RecQ protein-like 2
  • EC 3.1
  • Exonuclease WRN
  • RECQL2Werner syndrome ATP-dependent helicase
  • RECQ3RECQL3
  • DKFZp686C2056
  • Werner syndrome, RecQ helicase-like

Research Areas for WRN

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Repair
Genes Sensitive to DNA Damaging Agents
Tumor Suppressors

Bioinformatics Tool for WRN

Discover related pathways, diseases and genes to WRN. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related WRN Blog Posts

Check out the latest blog posts on WRN.
Not as Pluripotent as You Used to Be: Embryonic Stem Cell Markers and the Aging Process
We at Novus Biologicals recently extended our antibody catalog to include several embryonic stem cells (ESC) antibodies validated for use in FACS (fluorescent activated cell sorting) assays. Among them was Oct4, which recently became the focus of an i...    Read more.
Read more WRN related blogs.