WRN Products

Description

WRN encodes a member of the RecQ subfamily and the DEAH (Asp-Glu-Ala-His) subfamily of DNA and RNA helicases. DNA helicases are involved in many aspects of DNA metabolism, including transcription, replication, recombination, and repair. This protein contains a nuclear localization signal in the C-terminus and shows a predominant nucleolar localization. It possesses an intrinsic 3' to 5' DNA helicase activity, and is also a 3' to 5' exonuclease. Based on interactions between this protein and Ku70/80 heterodimer in DNA end processing, this protein may be involved in the repair of double strand DNA breaks. Defects in this gene are the cause of Werner Syndrome, an autosomal recessive disorder characterized by premature aging.

Bioinformatics

Entrez	7486 Human
Uniprot	NP_000544 Human Q14191 Human
Product By Gene ID	7486
Alternate Names	DKFZp686C2056 DNA helicase, RecQ-like type 3 EC 3.1 EC 3.6.1 EC 3.6.4.12 Exonuclease WRN RecQ protein-like 2 RecQ3 RECQ3RECQL3 RECQL2Werner syndrome ATP-dependent helicase Werner syndrome Werner syndrome, RecQ helicase-like

Research Areas for WRN

Find related products by research area and learn more about each of the different research areas below.

Cancer
DNA Repair
Genes Sensitive to DNA Damaging Agents
Tumor Suppressors

Related WRN Blog Posts

Check out the latest blog posts on WRN.

Not as Pluripotent as You Used to Be: Embryonic Stem Cell Markers and the Aging Process We at Novus Biologicals recently extended our antibody catalog to include several embryonic stem cells (ESC) antibodies validated for use in FACS (fluorescent activated cell sorting) assays. Among them was Oct4, which recently became the focus of an i...    Read more.

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