WHSC2 Products

Description

WHSC2 is expressed ubiquitously with higher levels in fetal than in adult tissues. Wolf Hirschhorn syndrome (WHS) is a malformation syndrome associated with a hemizygous deletion of the distal short arm of chromosome 4. This gene is mapped to the 165 kb WHS critical region, and may play a role in the phenotype of the WHS or Pitt Rogers Danks syndrome. The encoded protein is found to be capable of reacting with HLA A2 restricted and tumor specific cytotoxic T lymphocytes, suggesting a target for use in specific immunotherapy for a large number of cancer patients. This protein has also been shown to be a member of the NELF (negative elongation factor) protein complex that participates in the regulation of RNA polymerase II transcription elongation.

Bioinformatics

Entrez	7469 Human 305455 Rat
Product By Gene ID	7469
Alternate Names	FLJ10442 negative elongation factor A NELFA NELF-AFLJ25112 Wolf-Hirschhorn syndrome candidate 2 protein Wolf-Hirschhorn syndrome candidate 2

Research Areas for WHSC2

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Cancer