VRL1 Products

Description

Caterina et al has identified a structurally related receptor, VRL-1, that does not respond to capsaicin, acid or moderate heat. Instead, VRL-1 is activated by high temperatures, with a threshold of approximately 52 degrees C. Within sensory ganglia, VRL-1 is most prominently expressed by a subset of medium- to large-diameter neurons, making it a candidate receptor for transducing high-threshold heat responses in this class of cells. VRL-1 transcripts are not restricted to the sensory nervous system, indicating that this channel may be activated by stimuli other than heat. VRL-1 is one of the six members of the vanilloid-like TRP-channel family which is now known as TRPV family. FUNCTION: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. SUBUNIT: Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with RGA. SUBCELLULAR LOCATION: Cell membrane; multi-pass membrane protein. Cytoplasm. Translocates from the cytoplasm to the plasma membrane upon ligand stimulation. TISSUE SPECIFICITY: Ubiquitously expressed. Expressed in dorsal root ganglia, trigeminal ganglia, spinal chord (Lissauer's tract, dorsal horn and dorsal columns) (at protein level). PTM: N-glycosylated. PTM: Phosphorylated by PKA. SIMILARITY: Belongs to the transient receptor family. TrpV subfamily. SIMILARITY: Contains 3 ANK repeats.

Bioinformatics

Entrez	51393 Human 22368 Mouse 29465 Rat
Uniprot	Q9Y5S1 Human NP_057197.2 Human Q9WTR1 Mouse
Product By Gene ID	51393
Alternate Names	TrpV2 Osm-9-like TRP channel 2 VRL1transient receptor potential cation channel subfamily V member 2 VRL-1MGC12549 VRLOTRPC2 Vanilloid receptor-like protein 1 transient receptor potential cation channel, subfamily V, member 2

Diseases related to VRL1

Discover more about diseases related to VRL1.

Pain
Inflammation
Hyperalgesia
Malignant Neoplasms
Dystrophy
Neuralgia
Thermal Hyperalgesia
Muscular Dystrophy
Muscular Dystrophy, Duchenne
Neurogenic Inflammation
Insulinoma
Malignant Neoplasm Of Prostate
Hypertensive Disease
Carcinoma
Neoplasms
Pathologic Neovascularization
Prostatic Neoplasms
Hyperalgesias, Mechanical
Coughing

Pathways for VRL1

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Localization
Secretion
Hypersensitivity
Cell Proliferation
Sensitization
Pathogenesis
Insulin Secretion
Cell Death
Innervation
Reflex
Reverse Transcription
Membrane Depolarization
Cell Growth
Cell Migration
Regulation Of Growth
Glycosylation
Excretion
Transport
Regulation Of Insulin Secretion
Cell Activation

Research Areas for VRL1

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Signal Transduction

PTMs for VRL1

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Phosphorylation
Glycosylation
Cleavage
Oxidation
Deglycosylation

Bioinformatics Tool for VRL1

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