VRL1 Products

VRL1 Antibody
VRL1 Antibody
Species: Hu, Mu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
VRL1 Antibody
VRL1 Antibody
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
VRL1 Antibody
VRL1 Antibody
Species: Hu, Po, Eq, Pm, Bv, Ha, Pm, Rb
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
VRL1 Overexpression Lysate
VRL1 Overexpression Lysate
Species: Hu
Applications: WB
VRL1 Recombinant Protein Anti ...
VRL1 Recombinant Protein Antigen
Species: Hu
Applications: AC


Caterina et al has identified a structurally related receptor, VRL-1, that does not respond to capsaicin, acid or moderate heat. Instead, VRL-1 is activated by high temperatures, with a threshold of approximately 52 degrees C. Within sensory ganglia, VRL-1 is most prominently expressed by a subset of medium- to large-diameter neurons, making it a candidate receptor for transducing high-threshold heat responses in this class of cells. VRL-1 transcripts are not restricted to the sensory nervous system, indicating that this channel may be activated by stimuli other than heat. VRL-1 is one of the six members of the vanilloid-like TRP-channel family which is now known as TRPV family. FUNCTION: Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by growth factors, like IGF1, PDGF and morphogenetic neuropeptide/head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH. SUBUNIT: Homotetramer (Probable). Interacts with a cAMP-dependent protein kinase type II regulatory subunit (PRKAR2A or PRKAR2B) and ACBD3. Interacts with RGA. SUBCELLULAR LOCATION: Cell membrane; multi-pass membrane protein. Cytoplasm. Translocates from the cytoplasm to the plasma membrane upon ligand stimulation. TISSUE SPECIFICITY: Ubiquitously expressed. Expressed in dorsal root ganglia, trigeminal ganglia, spinal chord (Lissauer's tract, dorsal horn and dorsal columns) (at protein level). PTM: N-glycosylated. PTM: Phosphorylated by PKA. SIMILARITY: Belongs to the transient receptor family. TrpV subfamily. SIMILARITY: Contains 3 ANK repeats.


Entrez Human
Uniprot Human
Product By Gene ID 51393
Alternate Names
  • TrpV2
  • Osm-9-like TRP channel 2
  • VRL1transient receptor potential cation channel subfamily V member 2
  • VRL-1MGC12549
  • Vanilloid receptor-like protein 1
  • transient receptor potential cation channel, subfamily V, member 2

Research Areas for VRL1

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Signal Transduction

PTMs for VRL1

Learn more about PTMs related to VRL1.


Bioinformatics Tool for VRL1

Discover related pathways, diseases and genes to VRL1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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