VKORC1 Products

Description

Vitamin K is essential for blood clotting but must be enzymatically activated. This enzymatically activated form of vitamin K is a reduced form required for the carboxylation of glutamic acid residues in some blood-clotting proteins. The product of this gene encodes the enzyme that is responsible for reducing vitamin K 2,3-epoxide to the enzymatically activated form. Fatal bleeding can be caused by vitamin K deficiency and by the vitamin K antagonist warfarin, and it is the product of this gene that is sensitive to warfarin. In humans, mutations in this gene can be associated with deficiencies in vitamin-K-dependent clotting factors and, in humans and rats, with warfarin resistance. Two pseudogenes have been identified on chromosome 1 and the X chromosome. Two alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq]

Bioinformatics

Entrez	79001 Human
Uniprot	NP_076869.1 Human NP_996560 Human Q9BQB6 Human
Product By Gene ID	79001
Alternate Names	EC 1.1.4.1 EDTP308 FLJ00289 IMAGE3455200 MST576 phylloquinone epoxide reductase vitamin K dependent clMST134 vitamin K epoxide reductase complex subunit 1 vitamin K epoxide reductase complex, subunit 1 Vitamin K1 2,3-epoxide reductase subunit 1 vitamin K1 epoxide reductase (warfarin-sensitive) VKCFD2 VKORMGC2694