VAV3 Products

Antibodies
VAV3 Antibody
VAV3 Antibody
NB300-817
Species: Hu
Applications: WB, PEP-ELISA
Host: Goat Polyclonal
VAV3 Antibody
VAV3 Antibody
27210002
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
VAV3 Overexpression Lysate (N ...
VAV3 Overexpression Lysate (Native)
NBP2-07663
Applications: WB
VAV3 Overexpression Lysate (N ...
VAV3 Overexpression Lysate (Native)
NBP2-08481
Applications: WB
RNAi
VAV3 RNAi
VAV3 RNAi
H00010451-R01
Species: Hu

Description

The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav) (1). Vav3 is expressed in most hematopoietic cells and non-hematopoietic tissues except ovary and skeletal muscles. T-cell stimulated and tyrosine phosphorylated Vav3 acts as an exchange factor for GTP-binding proteins RhoA, RhoG, and Rac1 (2). Also, tyrosine phosphorylated Vav3 mediates RTK signalizing, specifically IR, IGFR, and EGFR-mediated signaling pathways. Vav3 has been linked to as a factor for cell morphology modulation and an inducer for cell transformation (3).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 10451
Alternate Names
  • guanine nucleotide exchange factor VAV3
  • FLJ40431
  • VAV-3
  • vav 3 oncogene
  • vav 3 guanine nucleotide exchange factor

Research Areas for VAV3

Find related products by research area and learn more about each of the different research areas below.

Phospho-Specific
Signal Transduction

PTMs for VAV3

Learn more about PTMs related to VAV3.

Phosphorylation
Methylation
Demethylation
Dephosphorylation
Ubiquitination

Bioinformatics Tool for VAV3

Discover related pathways, diseases and genes to VAV3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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