Species: Hu
Applications: ELISA, Flow, ICC/IF, IHC
Host: Goat Polyclonal
Species: Hu, Mu
Applications: WB, ICC/IF
Host: Rabbit Polyclonal
Species: Hu, Mu
Applications: WB, IHC
Host: Rabbit Monoclonal
Species: Hu
Applications: WB
Species: Hu
Applications: WB
Description
The Vav family are Rho/Rac guanosine nucleotide exchange factors (GEFs), consisting of three members in mammalian cells (Vav, Vav2, Vav3) and one in nematodes (CelVav) (1). Vav3 is expressed in most hematopoietic cells and non-hematopoietic tissues except ovary and skeletal muscles. T-cell stimulated and tyrosine phosphorylated Vav3 acts as an exchange factor for GTP-binding proteins RhoA, RhoG, and Rac1 (2). Also, tyrosine phosphorylated Vav3 mediates RTK signalizing, specifically IR, IGFR, and EGFR-mediated signaling pathways. Vav3 has been linked to as a factor for cell morphology modulation and an inducer for cell transformation (3).
Bioinformatics
| Entrez |
Human
Rat
Mouse
|
| Uniprot |
Human
Human
Human
Human
|
| Product By Gene ID |
10451 |
| Alternate Names |
- FLJ40431
- guanine nucleotide exchange factor VAV3
- vav 3 guanine nucleotide exchange factor
- vav 3 oncogene
- VAV-3
|
