USP48 Products

Description

Position of the Chimera RNAi. The related RNAi products listed were designed from different accesion number but sharing the same RNAi sequence. Chimera RNA interference (chimera RNAi) is process by which small interfering RNA/DNA chimera triggers the destruction of mRNA for the original gene.  The discovery work, design, and application of chimera RNAi has been pioneered by Professor Kaoru Saigo and Dr. Kumiko Ui-Tei at the University of Tokyo.  Chimera RNAi has many advantages over the conventional siRNAs.  First, it has been demonstrated to have reliable knock-down for over 10,000 human genes.  Because the human genome is composed of an intricate, genetic network, chimera RNAi's unique design has successfully obviated the off-target effects including microRNA-based influence.  Another advantage of the chimera RNAi technology is its effectiveness at low concentrations (0.5nM to 5nM); only mRNA is destroyed so genomic genes are not affected.  Finally, having both the sense and anti-sense strands consisting RNA/DNA chimera, it offers much greater compound stability for streamlining in vitro and in vivo assays and applications while minimizing interferon induction and other adverse reactions.

Bioinformatics

Product By Gene ID	84196
Alternate Names	Deubiquitinating enzyme 48 DKFZp762M1713 EC 3.1.2.15 EC 3.4.19.12 FLJ11328 FLJ20103 FLJ23054 FLJ23277 MGC132556 MGC14879 RAP1GA1 synUSP ubiquitin carboxyl-terminal hydrolase 48 ubiquitin specific peptidase 48 ubiquitin specific protease 31 ubiquitin specific protease 48 ubiquitin thioesterase 48 Ubiquitin thiolesterase 48 Ubiquitin-specific-processing protease 48 USP31 USP48