TRF-1 Products

Antibodies
TRF-1 Antibody (57-6)
TRF-1 Antibody (57-6)
NB110-68281
Species: Hu, Mu, Rt, Mk
Applications: WB, Simple Western, ELISA, Flow, ICC/IF (-)
Host: Mouse Monoclonal
TRF-1 Antibody
TRF-1 Antibody
NB600-1391
Species: Hu
Applications: WB
Host: Rabbit Polyclonal
TRF-1 Antibody
TRF-1 Antibody
AF5300
Species: Hu
Applications: WB
Host: Sheep Polyclonal
ELISA Kits
TRF-1 ELISA Kit [HRP]
TRF-1 ELISA Kit [HRP]
KA1977
Species: Rb
Lysates
TRF-1 Overexpression Lysate ( ...
TRF-1 Overexpression Lysate (Denat...
H00007013-T01
Species: Hu
Applications: WB
TRF-1 Overexpression Lysate ( ...
TRF-1 Overexpression Lysate (Native)
NBL1-16814
Applications: WB
Proteins
TRF-1 Recombinant Protein
TRF-1 Recombinant Protein
H00007013-P01
Species: Hu
Applications: WB, ELISA, PA
TRF-1 Partial Recombinant Pro ...
TRF-1 Partial Recombinant Protein
H00007013-Q01
Species: Hu
Applications: WB, ELISA, PA
RNAi
TRF-1 RNAi
TRF-1 RNAi
H00007013-R02
Species: Hu
TRF-1 RNAi
TRF-1 RNAi
H00007013-R01
Species: Hu

Description

Telomeric repeat binding factor 1 (TRF1, TERF1, PIN2, TRBF1) and telomeric repeat binding factor 2 (TRF2, TERF2, TRBF2) are present at telomeres throughout the cell cycle, where they regulate telomerase by acting in cis to limit the elongation of individual chromosome ends. Telomerase adds hexameric repeats of TTAGGG to the ends of chromosomal DNA. This telomerase enzyme plays an influential role in cellular immortalization and cellular senescence. TRF1 negatively regulates telomere elongation, while TRF2 protects the chromosome ends by inhibiting end-to-end fusions. Downregulation of TRF expression in tumor cells may contribute to cell immortalization and malignant progression. TRF1 has an acidic N-terminus while TRF2 has a basic N-terminus. TRF2 localizes in the nucleolus at G0 and S and diffuses out of the nucleolus in G2 phase. During mitosis TRF2 disperses from the condensed chromosomes and returns to the nucleolus at cytokinesis.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 7013
Alternate Names
  • TERF1
  • telomeric repeat-binding factor 1
  • NIMA-interacting protein 2
  • telomeric repeat binding protein 1
  • TRBF1
  • telomeric repeat binding factor 1
  • Telomeric protein Pin2/TRF1
  • TRFt-TRF1
  • PIN2hTRF1-AS
  • TRF1FLJ41416
  • TTAGGG repeat-binding factor 1
  • telomeric repeat binding factor (NIMA-interacting) 1

Research Areas for TRF-1

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Biology
Cell Cycle and Replication
Cellular Markers
Chromatin Research
Core ESC-Like Genes
Stem Cell Markers

PTMs for TRF-1

Learn more about PTMs related to TRF-1.

Methylation
Demethylation

Bioinformatics Tool for TRF-1

Discover related pathways, diseases and genes to TRF-1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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