TRAF-2 Products

Antibodies
Antibody Pairs
TRAF-2 Antibody Pair
TRAF-2 Antibody Pair
H00007186-PW1
Species: Hu
Applications: WB, IP
Lysates
TRAF-2 Knockout 293T Cell Lys ...
TRAF-2 Knockout 293T Cell Lysate
NBP2-65475
Species: Hu
Applications: WB
TRAF-2 Overexpression Lysate
TRAF-2 Overexpression Lysate
NBL1-17240
Species: Hu
Applications: WB
Proteins
Recombinant Human TRAF-2 Prot ...
Recombinant Human TRAF-2 Protein
H00007186-P01
Species: Hu
Applications: WB, ELISA, PA, AP
TRAF-2 Recombinant Protein An ...
TRAF-2 Recombinant Protein Antigen
NBP1-86913PEP
Species: Hu
Applications: AC
TRAF-2 Recombinant Protein An ...
TRAF-2 Recombinant Protein Antigen
NBP1-86914PEP
Species: Hu
Applications: AC

Description

The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis. TRAF2 is typically described as a 501 amino acid (aa) protein, GenBank no. NP_066961.2. However, various TRAF2 isoforms have been described. Therefore the molecular weight of TRAF2 detected by Western blot may vary depending on isoforms expressed.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Human
Human
Human
Mouse
Product By Gene ID 7186
Alternate Names
  • EC 6.3.2.-
  • E3 ubiquitin-protein ligase TRAF2
  • tumor necrosis factor type 2 receptor associated protein 3
  • Tumor necrosis factor type 2 receptor-associated protein 3
  • TRAP3TRAP
  • MGC:45012
  • TNF receptor-associated factor 2

Research Areas for TRAF-2

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cytokine Research
Zinc Finger

Bioinformatics Tool for TRAF-2

Discover related pathways, diseases and genes to TRAF-2. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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