TRAF-1 Products

Description

The TRAF (TNF receptor-associated factor) family is a group of adapter proteins (TRAFs 1-6) that link a wide variety of cell surface receptors to diverse signaling cascades leading to the activation of NF-kB and mitogen-activated protein kinases (reviewed in Chung et al, 2002). TRAFs are major signal transducers for both the TNF and IL- 1/TLR receptor superfamilies and collectively play important functions in both adaptive and innate immunity. The carboxy-terminal region of TRAFs is required for self-association and interaction with receptor cytoplasmic domains following ligand-induced oligomerization. TRAFs interact with a variety of proteins that regulate receptor-induced cell death or survival, and TRAF-mediated signaling can promote cell survival or interfere with death receptor-induced apoptosis. This antibody recognizes TRAF1; human TRAF1 is a 416 amino acid protein.

Bioinformatics

Entrez	22029 Mouse 7185 Human
Uniprot	AAH24145 Human NM_005658 Human NP_005649 Human NP_005649.1 Human
Product By Gene ID	7185
Alternate Names	EBI6MGC:10353 Epstein-Bar virus-induced protein 6 Epstein-Barr virus-induced protein 6 TNF receptor-associated factor 1

Research Areas for TRAF-1

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cancer
Cytokine Research