TPX2 Products

Description

TPX2 (targeting protein for XKLP2) is an ortholog of the Targeting Protein for Xenopus kinesin-like protein 2 (XKLP2) and was originally named restricted expression/proliferation-associated protein 100 (REPP86). TPX2 regulates the Xenopus kinesin-like protein 2 which is a plus end-directed microtubule motor required for centrosome separation and maintenance of spindle polarity during mitosis. TPX2 levels steadily increase during cell cycle progression with highest expression levels in M phase and lowest levels in G1 phase. TPX2 activates mitotic serine-threonine Aurora A kinase, nucleates microtubules and is considered as a critical factor for spindle assembly in mammalian mitotic cells. It is actively transported into the nucleus during interphase via importin alpha/beta receptors and this nuclear import sequesters TPX2 away from cytoplasmic tubulin to prevent premature spindle assembly. TPX2 haploinsufficiency, leading to decreased levels of TPX2, significantly increases the susceptibility for tumor development in mice and cells deficient in the Aurora A/TPX2 complex presents short spindles which, despite of being able to segregate chromosomes, result in mitotic failure.

Bioinformatics

Entrez	22974 Human 72119 Mouse 311546 Rat
Uniprot	Q9ULW0 Human
Product By Gene ID	22974
Alternate Names	C20orf1HCTP4 C20orf2 chromosome 20 open reading frame 1 Differentially expressed in cancerous and non-cancerous lung cells 2 differentially expressed in lung cells DIL2 DIL-2FLS353 HCA519 Hepatocellular carcinoma-associated antigen 519 P100 p100GD:C20orf1 preferentially expressed in colorectal cancer Protein fls353 REPP86 restricted expression proliferation associated protein 100 Restricted expression proliferation-associated protein 100 targeting protein for Xklp2 TPX2, microtubule-associated protein homolog TPX2, microtubule-associated, homolog (Xenopus laevis)

Research Areas for TPX2

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Biology
Cell Cycle and Replication
Chromatin Research
DNA Repair
Mitotic Regulators