TOP2A Products

Antibodies
TOP2A Antibody (2A9)
TOP2A Antibody (2A9)
Species: Hu
Applications: WB, IHC
Host: Mouse monoclonal
TOP2A Antibody
TOP2A Antibody
NBP1-86928
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
TOP2A Antibody
TOP2A Antibody
NBP1-01040
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
TOP2A Overexpression Lysate ( ...
TOP2A Overexpression Lysate (Native)
NBP2-10912
Applications: WB
Proteins
TOP2A Recombinant Protein Ant ...
TOP2A Recombinant Protein Antigen
NBP1-86928PEP
Species: Hu
Applications: AC
TOP2A Partial Recombinant Pro ...
TOP2A Partial Recombinant Protein
H00007153-Q01
Species: Hu
Applications: WB, ELISA, PA
TOP2A Recombinant Protein Ant ...
TOP2A Recombinant Protein Antigen
NBP1-86927PEP
Species: Hu
Applications: AC
RNAi
TOP2A RNAi
TOP2A RNAi
H00007153-R01
Species: Hu

Description

Topo II Alpha encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Product By Gene ID 7153
Alternate Names
  • DNA topoisomerase II, 170 kD
  • topoisomerase (DNA) II alpha (170kD)
  • DNA topoisomerase 2-alpha
  • EC 5.99.1.3
  • DNA topoisomerase (ATP-hydrolyzing)
  • DNA topoisomerase II, alpha isozyme
  • TOP2DNA gyrase
  • TP2A
  • topoisomerase (DNA) II alpha 170kDa

Research Areas for TOP2A

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cell Cycle and Replication
Core ESC-Like Genes
DNA Repair
Phospho-Specific
Stem Cell Markers

Bioinformatics Tool for TOP2A

Discover related pathways, diseases and genes to TOP2A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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