TOP2A Products

TOP2A Overexpression Lysate
TOP2A Overexpression Lysate
Species: Hu
Applications: WB
Recombinant Human TOP2A GST ( ...
Recombinant Human TOP2A GST (N-Ter...
Species: Hu
Applications: WB, ELISA, PA, AP
TOP2A Recombinant Protein Ant ...
TOP2A Recombinant Protein Antigen
Species: Hu
Applications: AC
TOP2A Recombinant Protein Ant ...
TOP2A Recombinant Protein Antigen
Applications: AC


Topo II Alpha encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromsome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia.


Entrez Human
Uniprot Human
Product By Gene ID 7153
Alternate Names
  • DNA topoisomerase II, 170 kD
  • topoisomerase (DNA) II alpha (170kD)
  • DNA topoisomerase 2-alpha
  • EC
  • DNA topoisomerase (ATP-hydrolyzing)
  • DNA topoisomerase II, alpha isozyme
  • TOP2DNA gyrase
  • TP2A
  • topoisomerase (DNA) II alpha 170kDa

Research Areas for TOP2A

Find related products by research area and learn more about each of the different research areas below.

Cell Cycle and Replication
Core ESC-Like Genes
DNA Repair
Stem Cell Markers

Bioinformatics Tool for TOP2A

Discover related pathways, diseases and genes to TOP2A. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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