WB, Flow, Flow-ICHost:
Applications: WB, Flow
Host: Rabbit Monoclonal
Host: Mouse Monoclonal
The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules (1). The TLR family is a phylogenetically conserved mediator of innate immunity that is essential for microbial recognition (2). TLR11 does not respond to known TLR ligands but instead respond specifically to uropathogenic bacteria. TLR11-deficient mice are highly susceptible to infection of the kidneys by uropathogenic bacteria, indicating that TLR11 may play a protective role in preventing infection of internal organs of the urogenital system.
|Product By Gene ID
Bioinformatics Tool for TLR12
Discover related pathways, diseases and genes to TLR12. Need help? Read the Bioinformatics Tool Guide
for instructions on using this tool.