TIMM50 Products

Antibodies
TIMM50 Antibody
TIMM50 Antibody
NBP2-38791
Species: Hu, Mouse, Rat
Applications: WB, ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
TIMM50 Antibody
TIMM50 Antibody
NB100-1462
Species: Hu
Applications: WB, PEP-ELISA
Host: Goat Polyclonal
Lysates
TIMM50 Overexpression Lysate ...
TIMM50 Overexpression Lysate (Native)
NBP2-08987
Applications: WB
Proteins
TIMM50 Partial Recombinant Pr ...
TIMM50 Partial Recombinant Protein
H00092609-Q01
Species: Hu
Applications: WB, ELISA, PA
TIMM50 Recombinant Protein An ...
TIMM50 Recombinant Protein Antigen
NBP2-38791PEP
Species: Hu
Applications: AC
RNAi
TIMM50 RNAi
TIMM50 RNAi
H00092609-R01
Species: Hu

Description

Tim50 is a component of the yeast Tim23 import machinery, which mediates translocation of presequence containing proteins across the mitochondrial inner membrane. By searching sequence databases, open reading frames encoding proteins with similarity to Tim50 and with a putative mitochondrial presequence were identified in the genomes of evolutionarily distant organisms, including human. Tim50 was found to interact with the N terminal intermembrane space domain of Tim23. Functional defects of Tim50 either by depletion of the protein or addition of anti Tim50 antibodies blocked the protein translocation across the inner membrane. A translocation intermediate accumulated at the translocator of the outer mitochondrial membrane (TOM) complex was cross linked to Tim50. Thus it can be concluded that Tim50, in cooperation with Tim23, facilitates transfer of the translocating protein from the TOM complex to the Tim23 complex.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Human
Product By Gene ID 92609
Alternate Names
  • Tim50-like protein
  • translocase of inner mitochondrial membrane 50 homolog (yeast)
  • mitochondrial import inner membrane translocase subunit TIM50
  • TIM50
  • homolog of yeast Tim50
  • TIM50L
  • MGC102733
  • translocase of inner mitochondrial membrane 50 homolog (S. cerevisiae)

Pathways for TIMM50

View related products by pathway and learn more about each of the pathways below.

Transport
Mitochondrial Transport
Translation
Cellular Localization
Histone Acetylation
Cell Growth
Localization
Oncogenesis

PTMs for TIMM50

Learn more about PTMs related to TIMM50.

Acetylation

Bioinformatics Tool for TIMM50

Discover related pathways, diseases and genes to TIMM50. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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