THEM4 Products

Description

Protein kinase B (PKB) is a major downstream target of receptor tyrosine kinases that signal via phosphatidylinositol 3-kinase. Upon cell stimulation, PKB is translocated to the plasma membrane, where it is phosphorylated in the C-terminal regulatory domain. The protein encoded by this gene negatively regulates PKB activity by inhibiting phosphorylation. Transcription of this gene is commonly downregulated in glioblastomas. [provided by RefSeq]

Bioinformatics

Entrez	117145 Human
Uniprot	Q5T1C6 Human AAH65277.1 Human NP_444283 Human NP_444283.2 Human
Product By Gene ID	117145
Alternate Names	C-terminal modulator protein MGC29636 CTMPCarboxyl-terminal modulator protein thioesterase superfamily member 4

Diseases related to THEM4

Discover more about diseases related to THEM4.

Neoplasms
Malignant Neoplasms
Cell Transformation, Neoplastic
Optic Atrophy
Sclerosis
Non-neoplastic Disorder
Neoplasms, Experimental
Glioma
Hypoxia
Carcinoma
Dysplasia
Fibrosis
Cortical Dysplasia
L1 Acute Lymphoblastic Leukemia
Fatty Liver
Adenocarcinoma
Non-small Cell Lung Carcinoma
Congenital Neurologic Anomalies

Pathways for THEM4

View related products by pathway and learn more about each of the pathways below.

Localization
Cell Death
Pathogenesis
Transport
Oxygen Homeostasis
Liver Development
Demethylation
Glucose Homeostasis
Mitochondrial Fusion
Methylation
Sensitization
Membrane Depolarization
Cell Growth
Glucose Transport

PTMs for THEM4

Learn more about PTMs related to THEM4.

Phosphorylation
Cleavage
Methylation
Demethylation

Bioinformatics Tool for THEM4

Discover related pathways, diseases and genes to THEM4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.