TCTN3 Products

Description

TCTN3 is a member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. While the expression pattern and function of TCTN3 is not known, it is 58% similar to TCTN1. TCTN1 is expressed during embryonic development in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.

Bioinformatics

Uniprot	NP_056446 Human
Product By Gene ID	26123
Alternate Names	C10orf61 chromosome 10 open reading frame 61 DKFZP564D116 TECT3DKFZp564D116 tectonic 3 tectonic family member 3 tectonic-3

Research Areas for TCTN3

Find related products by research area and learn more about each of the different research areas below.

Apoptosis
Cell Biology