Tapasin Related Protein Products

Description

TAP-binding protein-like (TAPBPL), also known as TAP binding protein-related (TAPBPR) and Tapasin-related protein (TAPASINR) is a transmembrane protein of the Immunoglobulin (Ig) superfamily (1, 2). TAPBPR was originally isolated as a homologue to TAPASIN but more recently was identified as a novel B7 family-related molecule since it shares sequence, structural, and functional similarities to B7 family members (3). Mature human TAPBPR consists of a lumenal domain containing an IgV and IgC domain, a transmembrane domain, and a cytoplasmic tail which lacks an ER retention motif. Within the lumenal domain, mature human TAPBPR shares 70% and 71% amino acid sequence identity with mouse and rat TAPBPR, respectively. Multiple alternatively spliced TAPBPR isoforms are known to exist with unique properties (4).TAPBPR is widely expressed and, similar to TAPASIN, functions as a both a chaperone protein and peptide editor of MHC class I, but in a peptide‑loading complex (PLC) independent manner (5, 6). TAPBPR decreases the rate at which MHC class I molecules mature through the secretory pathway, a role which could be important for peptide selection by MHC class I molecules (7). TAPBPR is also expressed on the surface of T cells and antigen-presenting cells (APCs) and plays an inhibitory role in the proliferation and activation of T cells (4). TAPBPR can be expressed on various cancer cells like leukemia and has the potential to be used in the treatment of autoimmune diseases and transplant rejection, as well as cancer (4).

Bioinformatics

Uniprot	Q9BX59.2
Product By Gene ID	55080
Alternate Names	FLJ10143 TAP binding protein-like Tapasin Related Protein/TAPBPR Tapasin-like TAPASIN-R tapasin-related protein TAP-binding protein-like TAP-binding protein-related protein TAPBPL TAPBPR TAPBP-RTAP binding protein related TAPBPRtapasin-like

Diseases related to Tapasin Related Protein

Discover more about diseases related to Tapasin Related Protein.

Burkitt Lymphoma
Alzheimer's Disease
Transient Ischemic Attack
Multiple Acyl Coenzyme A Dehydrogenase Deficiency
Dysequilibrium Syndrome

Pathways for Tapasin Related Protein

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Translation
Localization

PTMs for Tapasin Related Protein

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Biotinylation