TAF12 Products

Description

Control of transcription by RNA polymerase II involves the basal transcription machinery which is a collection of proteins. These proteins with RNA polymerase II, assemble into complexes which are modulated by transactivator proteins that bind to cis-regulatory elements located adjacent to the transcription start site. Some modulators interact directly with the basal complex, whereas others may act as bridging proteins linking transactivators to the basal transcription factors. Some of these associated factors are weakly attached while others are tightly associated with TBP in the TFIID complex. Among the latter are the TAF proteins. Different TAFs are predicted to mediate the function of distinct transcriptional activators for a variety of gene promoters and RNA polymerases. TAF12 interacts directly with TBP as well as with TAF2I. Two transcript variants encoding the same protein have been found for this gene.

Bioinformatics

Entrez	6883 Human
Uniprot	AAH11986 Human NM_005644 Human NP_001128690 Human
Product By Gene ID	6883
Alternate Names	20kDa TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor TAF15 TAF2J TAFII-20/TAFII-15 TAFII20TAFII20/TAFII15 TATA box binding protein (TBP)-associated factor, RNA polymerase II, J, 20kD Transcription initiation factor TFIID 20/15 kDa subunits transcription initiation factor TFIID subunit 12