T-bet/TBX21 Products

Description

Tbx21 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human ortholog of mouse Tbx21/Tbet gene. Studies in mouse show that Tbx21 protein is a Th1 cell-specific transcription factor that controls the expression of the hallmark Th1 cytokine, interferon-gamma (IFNG). Expression of the human ortholog also correlates with IFNG expression in Th1 and natural killer cells, suggesting a role for this gene in initiating Th1 lineage development from naive Th precursor cells. [provided by RefSeq]

Bioinformatics

Entrez	30009 Human
Uniprot	AAH39739 Human AAH39739.1 Human NP_037483 Human Q9UL17 Human
Product By Gene ID	30009
Alternate Names	T-bet TBETT-PET TBLYMT-cell-specific T-box transcription factor T-bet T-box 21 T-box expressed in T cells T-box protein 21 T-box transcription factor TBX21 Transcription factor TBLYM