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Syntaxin 3 is a member of the SNARE family of proteins and is related to syntaxin 1. While often co-expressed with syntaxins 2 and 4 within the same cell type, its membrane localization is usually different, for instance in epithelial cells or in the exocrine pancreas. Like syntaxins 1,2, and 4 it appears to be involved in the fusion of transport vesicles with the plasma membrane.