Synapsin I Products

Description

Synapsin I is a member of neuron-specific phosphoproteins that associate with synaptic vesicles (1). Three mammalians synapsins have been identified, Synapsin I, II and III. Generated by differential splicing, Synapsin Ia and Synapsin Ib differ in their Carboxyl termini (2). Synapsin I also functions in binding synaptic vesicles to several elements of the cytoskeleton including actin filaments, microtubules and spectrin. (3) Fairly abundant protein of the brain (0.4%), Synapsin I is best known to be CaM kinase II substrate in addition to cAMP-dependent protein kinase. (4) Phosphorylation at site Ser 566 and Ser 603 by CaM kinase II will cause a 5 fold decrease in the affinity of synaptic vesicles binding (5).

Bioinformatics

Entrez	6853 Human 20964 Mouse 24949 Rat
Uniprot	P17600 Human
Product By Gene ID	6853
Alternate Names	SYN1 SYN1a SYN1b Synapsin 1 Synapsin I synapsin IBrain protein 4.1 synapsin-1 SYNI

Research Areas for Synapsin I

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Neuronal Cell Markers
Neuroscience
Phospho-Specific

Related Synapsin I Blog Posts

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Synapsin I, a pre-synaptic marker Synapsin-I, also called Synapsin 1/Syn1, is an ~80 kDa protein (predicted mol. wt. 74.1 kDa) which belongs to the Synapsin family (Synapsin I, Synapsin II, Synapsin III). Synapsins are the evolutionarily conserved phospho-proteins which are associ...    Read more.

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