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STAT3 Products

Antibodies
STAT3 [p Tyr705] Antibody [Un ...
STAT3 [p Tyr705] Antibody [Unconju...
Species: Hu
Applications: WB, Flow, CyTOF-ready, ICC/IF
Host: Rabbit Polyclonal
Formulation Catalog # Availability Price  
STAT3 Antibody (9D8)
STAT3 Antibody (9D8)
Species: Hu, Mu, Rt, Pm, Pm
Applications: WB, ICC/IF, IHC, IP, ChIP, KD
Host: Mouse Monoclonal
Lysates
STAT3 Overexpression Lysate
STAT3 Overexpression Lysate
NBL1-16525
Species: Hu
Applications: WB
STAT3 Overexpression Lysate
STAT3 Overexpression Lysate
NBL1-16526
Species: Hu
Applications: WB
Proteins
Recombinant Human STAT3 GST ( ...
Recombinant Human STAT3 GST (N-Ter...
H00006774-P01
Species: Hu
Applications: WB, ELISA, Func, MA, PAGE, AP
Recombinant Human STAT3 GST ( ...
Recombinant Human STAT3 GST (N-Ter...
H00006774-Q01
Species: Hu
Applications: WB, ELISA, MA, PAGE, AP, NULL
STAT3 Recombinant Protein Ant ...
STAT3 Recombinant Protein Antigen
NBP2-38857PEP
Species: Hu
Applications: AC

Description

Stat3 is a member of a group of proteins (Signal Transduction and Activators of Transcription) that act as both signal transducers for cytokines and growth factors, as well as transcription factors (1,2). Stats are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus (1). Stat3 is constitutively activated in a number of human tumors (3). Stat3 is activated by phosphorylation on tyrosine 705 which induces dimerization, nuclear translocation, and DNA binding While, Stat3-activated transcription seems to be regulated by serine phosphorylation at serine 727 (4)

Bioinformatics

Entrez Mouse
Rat
Human
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 6774
Alternate Names
  • Acute-phase response factor
  • APRFMGC16063
  • DNA-binding protein APRF
  • FLJ20882
  • HIES
  • signal transducer and activator of transcription 3 (acute-phase responsefactor)
  • signal transducer and activator of transcription 3

Research Areas for STAT3

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
Phospho-Specific
Signal Transduction
Transcription Factors and Regulators

Related STAT3 Blog Posts

Check out the latest blog posts on STAT3.
KLF4 as a transcription factor in stem cell differentiation
Kru¨ppel-like factors (KLFs) are evolutionarily conserved zinc finger transcription factors that play a role in cell differentiation, proliferation, and pluripotency. KLF4 has specifically been tied to many diverse cellular processes, including sel...    Read more.
Using a STAT3 antibody in chromatin immunoprecipitation (ChIP)
Signal transducer and activator of transcription 3 (STAT3) is an important oncogenic transcriptional factor that mediates tumor induced immune suppression.  Specifically, STAT3 transmits signals from cytokines and growth factor receptors in the pla...    Read more.
Survivin Acetylation: Affecting Apoptosis and Cancer
Survivin (BRIC5) is an inhibitor of apoptosis that also promotes cellular adaptation under stressful conditions and helps to regulate cell division. Recently, an antibody study by Dr. H Wang et al. at Brown University [PMID: 20826784] found that Survi...    Read more.
Thymoquinone: A Natural Product with Diverse Therapeutic Potential
Thymoquinone (2-isopropyl-5-methyl-1,4-benzoquinone, or TQ) is derived from the seeds of the black cumin plant Nigella sativa. It has been reported to have a number of beneficial properties including anti-oxidative, anti-inflammatory and anti-tumorige...    Read more.
Signal Transducer and Activator of Transcription STAT6: More than a Player in Allergic Inflammation
By Jamshed Arslan, Pharm. D., PhD. What is STAT6?The cellular pathway comprising tyrosine kinase Janus Kinase (JAK) and the transcription factor STAT connect extracellular signals from various cytokines, hormones an...    Read more.
HIF-1 beta - activating gene transcription in response to hypoxia
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor consisting of alpha and beta subunits. The levels of functional HIF-1 in the cell depends on the level of oxygen allowing cells to respond to hypoxic conditions. HIF-1a is a...    Read more.
HLA G - mediating immune tolerance during pregnancy
Human leukocyte antigen G (HLA G) is a major histocompatibility complex (MHC) class I molecule that is primarily expressed in the placenta and is essential for the immune tolerance of the fetus during pregnancy. Unlike many HLA genes, HLA G has re...    Read more.
TLR4 - A Guardian of Innate Immunity
Toll-like receptor 4 (TLR4) belongs to the family of Toll-like receptors (TLR), and plays a main role in pathogen recognition and innate immunity system activation. The TLR family members are highly conserved proteins that all contain a high degree of...    Read more.
Read more STAT3 related blogs.