STAT3 Products

Antibodies
STAT3 Antibody (232209) [Unco ...
STAT3 Antibody (232209) [Unconjuga...
MAB1799
Species: Hu, Mu, Rt
Applications: WB, IP, ICC, ICFlow
Host: Mouse Monoclonal
STAT3 Antibody (9D8)
STAT3 Antibody (9D8)
NBP2-22471
Species: Hu, Mu, Rt, Mk, Pm
Applications: WB, ChIP, ICC/IF, IHC, IHC-P, IP
Host: Mouse Monoclonal
STAT3 [p Tyr705] Antibody
STAT3 [p Tyr705] Antibody
NBP2-24463
Species: Hu, Mu, Ca, Pm
Applications: WB
Host: Rabbit Polyclonal
ELISA Kits
STAT3 [p Tyr705] ELISA Kit [H ...
STAT3 [p Tyr705] ELISA Kit [HRP]
KA2176
Species: Hu, Mu, Rt
STAT3 [p Tyr705] ELISA Kit [H ...
STAT3 [p Tyr705] ELISA Kit [HRP]
KA2175
Species: Hu, Mu, Rt
Lysates
STAT3 Overexpression Lysate ( ...
STAT3 Overexpression Lysate (Native)
NBL1-16525
Applications: WB
STAT3 Overexpression Lysate ( ...
STAT3 Overexpression Lysate (Native)
NBL1-16526
Applications: WB
STAT3 Overexpression Lysate ( ...
STAT3 Overexpression Lysate (Denat...
H00006774-T01
Species: Hu
Applications: WB
Proteins
Recombinant Human STAT3 Prote ...
Recombinant Human STAT3 Protein
H00006774-P01
Species: Hu
Applications: WB, ELISA, PA
Recombinant Human STAT3 Prote ...
Recombinant Human STAT3 Protein
H00006774-Q01
Species: Hu
Applications: WB, ELISA, PA
STAT3 Recombinant Protein Ant ...
STAT3 Recombinant Protein Antigen
NBP2-38857PEP
Species: Hu
Applications: AC
RNAi
STAT3 RNAi
STAT3 RNAi
H00006774-R03
Species: Hu
Applications: RNAi, RNAi SP
STAT3 RNAi
STAT3 RNAi
H00006774-R02
Species: Hu
Applications: RNAi, RNAi SP
STAT3 RNAi
STAT3 RNAi
H00006774-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

Stat3 is a member of a group of proteins (Signal Transduction and Activators of Transcription) that act as both signal transducers for cytokines and growth factors, as well as transcription factors (1,2). Stats are activated by tyrosine phosphorylation in response to different ligands, after which they translocate to the cell nucleus (1). Stat3 is constitutively activated in a number of human tumors (3). Stat3 is activated by phosphorylation on tyrosine 705 which induces dimerization, nuclear translocation, and DNA binding While, Stat3-activated transcription seems to be regulated by serine phosphorylation at serine 727 (4)

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Human
Human
Human
Human
Human
Product By Gene ID 6774
Alternate Names
  • signal transducer and activator of transcription 3
  • HIES
  • DNA-binding protein APRF
  • Acute-phase response factor
  • APRFMGC16063
  • FLJ20882
  • signal transducer and activator of transcription 3 (acute-phase responsefactor)

Research Areas for STAT3

Find related products by research area and learn more about each of the different research areas below.

Cellular Markers
Phospho-Specific
Signal Transduction
Transcription Factors and Regulators

Bioinformatics Tool for STAT3

Discover related pathways, diseases and genes to STAT3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
Vizit™, under license from BioVista Inc.

Related STAT3 Blog Posts

Check out the latest blog posts on STAT3.
Using a STAT3 antibody in chromatin immunoprecipitation (ChIP)
Signal transducer and activator of transcription 3 (STAT3) is an important oncogenic transcriptional factor that mediates tumor induced immune suppression.  Specifically, STAT3 transmits signals from cytokines and growth factor receptors in the pla...    Read more.
KLF4 as a transcription factor in stem cell differentiation
Kru¨ppel-like factors (KLFs) are evolutionarily conserved zinc finger transcription factors that play a role in cell differentiation, proliferation, and pluripotency. KLF4 has specifically been tied to many diverse cellular processes, including sel...    Read more.
HLA G - mediating immune tolerance during pregnancy
Human leukocyte antigen G (HLA G) is a major histocompatibility complex (MHC) class I molecule that is primarily expressed in the placenta and is essential for the immune tolerance of the fetus during pregnancy. Unlike many HLA genes, HLA G has re...    Read more.
HIF-1 beta - activating gene transcription in response to hypoxia
Hypoxia-inducible factor 1 (HIF-1) is a heterodimeric transcription factor consisting of alpha and beta subunits. The levels of functional HIF-1 in the cell depends on the level of oxygen allowing cells to respond to hypoxic conditions. HIF-1a is a...    Read more.
TLR4 - A Guardian of Innate Immunity
Toll-like receptor 4 (TLR4) belongs to the family of Toll-like receptors (TLR), and plays a main role in pathogen recognition and innate immunity system activation. The TLR family members are highly conserved proteins that all contain a high degree of...    Read more.
Thymoquinone: A Natural Product with Diverse Therapeutic Potential
Thymoquinone (2-isopropyl-5-methyl-1,4-benzoquinone, or TQ) is derived from the seeds of the black cumin plant Nigella sativa. It has been reported to have a number of beneficial properties including anti-oxidative, anti-inflammatory and anti-tumorige...    Read more.
Survivin Acetylation: Affecting Apoptosis and Cancer
Survivin (BRIC5) is an inhibitor of apoptosis that also promotes cellular adaptation under stressful conditions and helps to regulate cell division. Recently, an antibody study by Dr. H Wang et al. at Brown University [PMID: 20826784] found that Survi...    Read more.
Read more STAT3 related blogs.