STARD4 Products

Description

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD4 (Soccio et al., 2002 [PubMed 12011452]).[supplied by OMIM]

Bioinformatics

Entrez	134429 Human
Uniprot	NP_631903.1 Human
Product By Gene ID	134429
Alternate Names	StARD4 StAR-related lipid transfer (START) domain containing 4 stAR-related lipid transfer protein 4 START domain containing 4 sterol-regulated START domain-containing protein 4 sterol regulated