sRank Receptor/TNFRSF11A Products

Description

RANK Ligand and RANK Receptor are members of the TNF superfamily that play an important role in the regulation of specific immunity and bone turnover. RANK Receptor was originally identified as a dendritic-cell-membrane protein, which by interacting with RANKL augments the ability of dendritic cells to stimulate naive T cell proliferation and to promote the survival of RANK + T cells. RANK is also expressed in a variety of tissues including skeletal muscle, thymus, liver, colon, small intestine and adrenal gland. The RANK/RANKL interaction is important in the regulation of osteoclastogenesis and in dendritic-cellmediated T cell immune responses. Impairments in RANK signaling have been implicated in the induction of expansile osteolysis and Paget disease of bone (PDB2). Recombinant human sRANK receptor is a 19.1 kDa polypeptide containing the TNFR homologous cysteine rich portion of the extracellular domain of RANK receptor (174 amino acid residues).

Bioinformatics

Uniprot	Q9Y6Q6 Q9Y6Q6 Q9Y6Q6
Product By Gene ID	8792
Alternate Names	CD265 antigen CD265 FEO loss of heterozygosity, 18, chromosomal region 1 OFE OPTB7 Osteoclast differentiation factor receptor PDB2 Receptor activator of NF-KB receptor activator of nuclear factor-kappa B TRANCER tumor necrosis factor receptor superfamily member 11A tumor necrosis factor receptor superfamily, member 11a, activator of NFKB tumor necrosis factor receptor superfamily, member 11a, NFKB activator