Hu, Mu, RtApplications:
WB, Flow, ICC/IF, IHC, IPHost:
High density lipoproteins (HDLs) play a critical role in cholesterol metabolism. This is evident in that their plasma concentrations are inversely correlated with risk for atherosclerosis. SR-BI and SR-BII (previously known as SR-BI.2) are the alternatively spliced products of a single gene. SR-BII and SR-BI are identical except for the encoded c-terminal cytoplasmic domain. Both SR-BI and SR-BII bind HDL and mediates selective uptake of HDL cholesteryl ester, but with SR-BII having an approximately 4-fold lower efficiency than SR-BI. SR-BI and SR-BII are expressed primarily in liver and non-placental steroidgenic tissues. Although the role of these scavenger receptors is not completely clear, SR-BII mRNA results from the alternative splicing of SR-BI precursor transcripts with both isoforms mediating selective transfer of lipid between HDL and cells. Therefore, the relative expression and functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.
|Product By Gene ID
- CD36 antigen
- Collagen type I receptor, thrombospondin receptor-like 1
- scavenger receptor class B type III
- CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
- CD36L1scavenger receptor class B type 1
- SRB1scavenger receptor class B member 1
- CLA1CD36 antigen-like 1
- CD36 and LIMPII analogous 1
- scavenger receptor class B, member 1
Bioinformatics Tool for SR-BI/SR-BII
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