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SR-BI/SR-BII Products

Antibodies
SR-BI/SR-BII Antibody - BSA F ...
SR-BI/SR-BII Antibody - BSA Free
NB400-134
Western Blot SR-BI/SR-BII Antibody - BSA Free
Immunocytochemistry/ Immunofluorescence SR-BI/SR-BII Antibody - BSA Free
Immunohistochemistry-Paraffin SR-BI/SR-BII Antibody - BSA Free
Flow Cytometry SR-BI/SR-BII Antibody - BSA Free
Species: Hu, Mu, Rt
Applications: WB, Flow, ICC/IF, IHC, IP, B/N, IHC-Fr (-), KO
Host: Rabbit Polyclonal
Formulation Catalog # Availability Price  
BSA Free NB400-134SS
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We have 1 SR-BI/SR-BII Antibody

Description

SR-BI (scavenger receptor class BI, SCARB1) is a member of the CD36 receptor family and acts as a major receptor for HDL for facilitating selective lipid uptake from lipoproteins in several tissues. The SR-BI gene gives rise to at least two mRNA splice variants (SR-BI and SR-BII), with the SR-BII variant being the main isoform in terms of mRNA levels in certain tissues, for example SR-BII mRNA is 48-fold higher in concentration than SR-BI in brain cells. Similar differential SR-BII protein expression levels have also been detected in considerable amounts in other tissues, such as testes, retinal pigment epithelial cells, and spleen. SR-BII isoform differs from SR-BI only in its entirely different, yet highly conserved, cytoplasmic C-terminus which has been proposed to contains a signal responsible for marked alterations in cellular distribution as well as cellular trafficking of SR-BII compared with SR-BI. In contrast to SR-BI, SR-BII mediates the rapid uptake of significant amounts of HDL into endosomal recycling compartment by a pathway which is different from selective lipid uptake at the cell surface (mediated by SR-BI). Because SR-BII influences cellular cholesterol trafficking/homeostasis in a manner distinct from SR-BI, the relative expression as well as functional activities of these two isoforms create a potential means of regulating selective lipid transfer between HDL and cells.

Bioinformatics

Entrez
20778
Mouse
Uniprot
O35114

Q61009
Mouse
Product By Gene ID 949
Alternate Names
  • CD36 and LIMPII analogous 1
  • CD36 antigen (collagen type I receptor, thrombospondin receptor)-like 1
  • CD36 antigen
  • CD36L1scavenger receptor class B type 1
  • CLA1CD36 antigen-like 1
  • CLA-1HDLQTL6
  • Collagen type I receptor, thrombospondin receptor-like 1
  • scavenger receptor class B type III
  • scavenger receptor class B, member 1
  • SRB1scavenger receptor class B member 1
  • SR-BIMGC138242

Research Areas for SR-BI/SR-BII

Find related products by research area and learn more about each of the different research areas below.

Cancer
Cholesterol Metabolism
Lipid and Metabolism
Signal Transduction