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HAF016). A specific band was detected for SPRY4 at approximately 35 kDa (as indicated). This experiment was conducted under reducing conditions and using Immunoblot Buffer Group 1." class="big_lightbox" target="_blank">
HAF016). This experiment was conducted under reducing conditions and using the 12-230 kDa separation system." class="big_lightbox" target="_blank">
Sprouty-4 (also known as SPRY4) is an inhibitor of the insulin receptor and EGFR-transduced mitogen-activated protein kinase (MAPK) signaling pathway downstream of FGF and EGF receptor tyrosine kinase activation. It is positioned upstream of RAS activation and impairs the formation of active GTP-RAS. SPRY4 is widely expressed, with different isoforms. The protein consists of 322 amino acids, with a cysteine-rich region, Src homology 3 binding regions, proline-rich regions, and a PEST sequence. It is expressed predominantly in the cytoplasm. Northern results show bands across most tissues, with strongest expression in heart, brain, placenta, lung, and intestine.
![Western Blot SPRY4 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/SPRY4_AF5070_Western_Blot_5619.jpg)
![Simple Western SPRY4 Antibody [Unconjugated]](http://images.novusbio.com/images/antibody/SPRY4_AF5070_Simple_Western_17522.jpg)
![Western Blot SPRY4 Antibody [Unconjugated]](http://images.novusbio.com/fullsize/af5070_human-spry4-affinity-purified-polyclonal-ab-4120241240256.jpg)
