SPRY4 Products

Antibodies
SPRY4 Antibody [Unconjugated] ...
SPRY4 Antibody [Unconjugated]
AF5070
Species: Hu
Applications: WB, Simple Western
Host: Sheep Polyclonal
SPRY4 Antibody
SPRY4 Antibody
NB100-2032
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
Host: Rabbit Polyclonal
SPRY4 [p Tyr75] Antibody
SPRY4 [p Tyr75] Antibody
NBP2-30084
Species: Hu
Applications: WB, Flow, IHC-P
Host: Rabbit Polyclonal
Lysates
SPRY4 Overexpression Lysate ( ...
SPRY4 Overexpression Lysate (Native)
NBP2-06152
Applications: WB
Proteins
SPRY4 Recombinant Protein
SPRY4 Recombinant Protein
NBP2-22822
Species: Hu
Applications: PAGE

Description

Sprouty-4 (also known as SPRY4) is an inhibitor of the insulin receptor and EGFR-transduced mitogen-activated protein kinase (MAPK) signaling pathway downstream of FGF and EGF receptor tyrosine kinase activation. It is positioned upstream of RAS activation and impairs the formation of active GTP-RAS. SPRY4 is widely expressed, with different isoforms. The protein consists of 322 amino acids, with a cysteine-rich region, Src homology 3 binding regions, proline-rich regions, and a PEST sequence. It is expressed predominantly in the cytoplasm. Northern results show bands across most tissues, with strongest expression in heart, brain, placenta, lung, and intestine.

Bioinformatics

Entrez Human
Mouse
Uniprot Human
Human
Product By Gene ID 81848
Alternate Names
  • Spry-4
  • spry-4
  • protein sprouty homolog 4
  • sprouty homolog 4 (Drosophila)

Research Areas for SPRY4

Find related products by research area and learn more about each of the different research areas below.

Growth and Development
Neuronal Cell Markers
Signal Transduction

PTMs for SPRY4

Learn more about PTMs related to SPRY4.

Phosphorylation
Methylation
Cleavage
Dephosphorylation
Ubiquitination

Bioinformatics Tool for SPRY4

Discover related pathways, diseases and genes to SPRY4. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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