SPRY4 Products

Description

Sprouty-4 (also known as SPRY4) is an inhibitor of the insulin receptor and EGFR-transduced mitogen-activated protein kinase (MAPK) signaling pathway downstream of FGF and EGF receptor tyrosine kinase activation. It is positioned upstream of RAS activation and impairs the formation of active GTP-RAS. SPRY4 is widely expressed, with different isoforms. The protein consists of 322 amino acids, with a cysteine-rich region, Src homology 3 binding regions, proline-rich regions, and a PEST sequence. It is expressed predominantly in the cytoplasm. Northern results show bands across most tissues, with strongest expression in heart, brain, placenta, lung, and intestine.

Bioinformatics

Entrez	24066 Mouse 81848 Human
Uniprot	NP_112226 Human Q9C004 Human
Product By Gene ID	81848
Alternate Names	protein sprouty homolog 4 sprouty homolog 4 (Drosophila) Spry-4 spry-4

Research Areas for SPRY4

Find related products by research area and learn more about each of the different research areas below.

Growth and Development
Neuronal Cell Markers
Signal Transduction