SPG21 Products

Description

SPG21 is encoded by this gene was identified by a two-hybrid screen using CD4 as the bait. It binds to the hydrophobic C-terminal amino acids of CD4 which are involved in repression of T cell activation. The interaction with CD4 is mediated by the noncatalytic alpha/beta hydrolase fold domain of this protein. It is thus proposed that this gene product modulates the stimulatory activity of CD4. At least three different transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq]

Bioinformatics

Entrez	51324 Human
Uniprot	NM_016630 Human NP_001121361 Human NP_057714 Human NP_057714.1 Human
Product By Gene ID	51324
Alternate Names	Acid cluster protein 33 ACP33Spastic paraplegia 21 protein GL010 MASPARDIN maspardin MASTBM-019 spastic paraplegia 21 (autosomal recessive, Mast syndrome) Spastic paraplegia 21 autosomal recessive Mast syndrome protein

Research Areas for SPG21

Find related products by research area and learn more about each of the different research areas below.

Neurodegeneration