Spectrin beta 3 Products

Recombinant Human Spectrin be ...
Recombinant Human Spectrin beta 3 ...
Species: Hu
Applications: WB, ELISA, PA, AP
Spectrin beta 3 Recombinant P ...
Spectrin beta 3 Recombinant Protei...
Species: Hu
Applications: AC
Spectrin beta 3 Recombinant P ...
Spectrin beta 3 Recombinant Protei...
Species: Hu
Applications: AC


Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane.

Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. Mutations in spectrins are a previously unknown cause of ataxia and neurodegenerative disease that affect membrane proteins involved in glutamate signaling. Spectrin-beta IIIs have been recognized as ataxia disease genes and their mutations cause spinocerebellar ataxia type 5 (SCA5).


Entrez Human
Uniprot Human
Product By Gene ID 6712
Alternate Names
  • spinocerebellar ataxia 5
  • KIAA0302
  • SCA5
  • spectrin beta chain, brain 2
  • Spectrin, non-erythroid beta chain 2
  • glutamate transporter EAAT4-associated protein 41
  • Beta-III spectrin
  • GTRAP41
  • spectrin, beta, non-erythrocytic 2

Research Areas for Spectrin beta 3

Find related products by research area and learn more about each of the different research areas below.


PTMs for Spectrin beta 3

Learn more about PTMs related to Spectrin beta 3.


Bioinformatics Tool for Spectrin beta 3

Discover related pathways, diseases and genes to Spectrin beta 3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Vizit™, under license from BioVista Inc.