Spectrin beta 3 Products

Antibodies
Spectrin beta 3 Antibody
Spectrin beta 3 Antibody
NB110-58346
Species: Hu
Applications: WB, IHC, IHC-P, IP
Host: Rabbit Polyclonal
Spectrin beta 3 Antibody
Spectrin beta 3 Antibody
NB110-58783
Species: Hu
Applications: WB, ICC/IF, IHC, IHC-P, IP, WB (-)
Host: Rabbit Polyclonal
Proteins
Spectrin beta 3 Partial Recom ...
Spectrin beta 3 Partial Recombinan...
H00006712-Q01
Species: Hu
Applications: WB, ELISA, PA
Spectrin beta 3 Recombinant P ...
Spectrin beta 3 Recombinant Protei...
NBP2-48794PEP
Species: Hu
Applications: AC
Spectrin beta 3 Recombinant P ...
Spectrin beta 3 Recombinant Protei...
NBP2-48703PEP
Species: Hu
Applications: AC
RNAi
Spectrin beta 3 RNAi
Spectrin beta 3 RNAi
H00006712-R01
Species: Hu

Description

Spectrins are principle components of a cell's membrane-cytoskeleton and are composed of two alpha and two beta spectrin subunits. The protein encoded by this gene (SPTBN2), is called spectrin beta non-erythrocytic 2 or beta-III spectrin. It is related to, but distinct from, the beta-II spectrin gene which is also known as spectrin beta non-erythrocytic 1 (SPTBN1). SPTBN2 regulates the glutamate signaling pathway by stabilizing the glutamate transporter EAAT4 at the surface of the plasma membrane.

Mutations in this gene cause a form of spinocerebellar ataxia, SCA5, that is characterized by neurodegeneration, progressive locomotor incoordination, dysarthria, and uncoordinated eye movements. Mutations in spectrins are a previously unknown cause of ataxia and neurodegenerative disease that affect membrane proteins involved in glutamate signaling. Spectrin-beta IIIs have been recognized as ataxia disease genes and their mutations cause spinocerebellar ataxia type 5 (SCA5).

Bioinformatics

Entrez Human
Mouse
Rat
Uniprot Human
Human
Human
Human
Product By Gene ID 6712
Alternate Names
  • spinocerebellar ataxia 5
  • KIAA0302
  • SCA5
  • spectrin beta chain, brain 2
  • Spectrin, non-erythroid beta chain 2
  • glutamate transporter EAAT4-associated protein 41
  • Beta-III spectrin
  • GTRAP41
  • spectrin, beta, non-erythrocytic 2

Research Areas for Spectrin beta 3

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Neuroscience

PTMs for Spectrin beta 3

Learn more about PTMs related to Spectrin beta 3.

Cleavage

Bioinformatics Tool for Spectrin beta 3

Discover related pathways, diseases and genes to Spectrin beta 3. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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