SPAG6 Products

Description

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm antibodies from an infertile man. This protein localizes to the tail of permeabilized human sperm and contains eight contiguous armadillo repeats, a motif known to mediate protein-protein interactions. Studies in mice suggest that this protein is involved in sperm flagellar motility and maintenance of the structural integrity of mature sperm. Alternatively spliced variants that encode different protein isoforms have been described but the full-length sequences of only two have been determined.

Bioinformatics

Entrez	9576 Human
Uniprot	AAH30585 Human NM_172242 Human NP_036575 Human NP_036575.1 Human O75602 Human
Product By Gene ID	9576
Alternate Names	axoneme central apparatus protein DKFZp434I153 pf16 PF16 Protein PF16 homolog Repro-SA-1MGC26276 sperm associated antigen 6 Sperm flagellar protein sperm-associated antigen 6