SPAG1 Products

Antibodies
SPAG1 Antibody
SPAG1 Antibody
NBP2-47266
Species: Hu
Applications: ICC/IF, IHC, IHC-P
Host: Rabbit Polyclonal
SPAG1 Antibody
SPAG1 Antibody
NBP2-38707
Species: Hu
Applications: IHC, IHC-P
Host: Rabbit Polyclonal
Lysates
SPAG1 Overexpression Lysate ( ...
SPAG1 Overexpression Lysate (Native)
NBP2-08036
Applications: WB
Proteins
Recombinant Human SPAG1 Prote ...
Recombinant Human SPAG1 Protein
H00006674-Q01
Species: Hu
Applications: WB, ELISA, PA
SPAG1 Recombinant Protein Ant ...
SPAG1 Recombinant Protein Antigen
NBP2-47266PEP
Species: Hu
Applications: AC
SPAG1 Recombinant Protein Ant ...
SPAG1 Recombinant Protein Antigen
NBP2-38707PEP
Species: Hu
Applications: AC
RNAi
SPAG1 RNAi
SPAG1 RNAi
H00006674-R02
Species: Hu
Applications: RNAi, RNAi SP
SPAG1 RNAi
SPAG1 RNAi
H00006674-R01
Species: Hu
Applications: RNAi, RNAi SP

Description

The correlation of anti-sperm antibodies with cases of unexplained infertility implicates a role for these antibodies in blocking fertilization. Improved diagnosis and treatment of immunologic infertility, as well as identification of proteins for targeted contraception, are dependent on the identification and characterization of relevant sperm antigens. The protein expressed by this gene is recognized by anti-sperm agglutinating antibodies from an infertile woman. Furthermore, immunization of female rats with the recombinant human protein reduced fertility. This protein localizes to the plasma membrane of germ cells in the testis and to the post-acrosomal plasma membrane of mature spermatozoa. Recombinant polypeptide binds GTP and exhibits GTPase activity. Thus, this protein may regulate GTP signal transduction pathways involved in spermatogenesis and fertilization. Two transcript variants of this gene encode the same protein.

Bioinformatics

Entrez Human
Uniprot Human
Product By Gene ID 6674
Alternate Names
  • TPIS
  • TPR-containing protein involved in spermatogenesis
  • SP75
  • tetratricopeptide repeat-containing protein
  • FLJ32920
  • HSD-3.8sperm-associated antigen 1
  • Infertility-related sperm protein Spag-1
  • sperm associated antigen 1

Pathways for SPAG1

View related products by pathway and learn more about each of the pathways below.

Fertilization
Spermatogenesis
Pathogenesis
Cell Motility
Immune Response
Mitochondrial Dna Inheritance
Pachytene
Humoral Immune Response
Localization

PTMs for SPAG1

Learn more about PTMs related to SPAG1.

Phosphorylation

Bioinformatics Tool for SPAG1

Discover related pathways, diseases and genes to SPAG1. Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
 
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