SorLA Products

Description

SORL1 is likely to be a multifunctional endocytic receptor, that may be implicated in the uptake of lipoproteins and of proteases. It binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. SORL1 binds the receptor-associated protein (RAP). It could play a role in cell-cell interaction. SORL1 is expressed mainly in brain, where it is most abundant in the cerebellum, cerebral cortex and the occipital pole; low expression in the putamen and the thalamus. It is also found in spinal cord, testis, liver, kidney and pancreas with detectable levels in placenta, lung and heart. Moreover, it is expressed in the prostate, ovary, thyroid and spleen, but not found in kidney, liver, lung, skeletal muscle, bone marrow and adrenals.

Bioinformatics

Product By Gene ID

6653

Alternate Names

C11orf32 chromosome 11 open reading frame 32 FLJ21930 FLJ39258 gp250 Low-density lipoprotein receptor relative with 11 ligand-binding repeats LR11 LR11LDLR relative with 11 ligand-binding repeats LRP9 mosaic protein LR11 SORL1 SorLA SorLA-1SORLA sortilin-related receptor sortilin-related receptor, L(DLR class) A repeats containing sortilin-related receptor, L(DLR class) A repeats-containing Sorting protein-related receptor containing LDLR class A repeats