SOCS-7/Nck/NAP4 Products

Description

Regulates signaling cascades probably through protein ubiquitination and/or sequestration. Functions in insulin signaling and glucose homeostasis through IRS1 ubiquitination and subsequent proteasomal degradation. Inhibits also prolactin, growth hormone and leptin signaling by preventing STAT3 and STAT5 activation, sequestering them in the cytoplasm and reducing their binding to DNA. May be a substrate recognition component of a SCF-like E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins

Bioinformatics

Entrez	30837 Human
Uniprot	NM_014598 Human NP_055413 Human NP_055413.1 Human O14512 Human
Product By Gene ID	30837
Alternate Names	NAP-4 NAP4SOCS-7 Nck, Ash and phospholipase C binding protein Nck, Ash and phospholipase C gamma-binding protein NCKAP4 Nck-associated protein 4 SOCS6 suppressor of cytokine signaling 7

Research Areas for SOCS-7/Nck/NAP4

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Signal Transduction